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Structural white ma...
Structural white matter properties and cognitive resilience to tau pathology
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- Qiu, Ting (author)
- McGill University
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- Liu, Zhen Qi (author)
- Montreal Neurological Institute & Hospital
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- Rheault, François (author)
- Sherbrooke University
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- Legarreta, Jon Haitz (author)
- Harvard Medical School
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- Valcourt Caron, Alex (author)
- Sherbrooke University
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- St-Onge, Frédéric (author)
- McGill University
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- Strikwerda-Brown, Cherie (author)
- University of Western Australia, Perth,McGill University
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- Metz, Amelie (author)
- McGill University
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- Dadar, Mahsa (author)
- McGill University
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- Soucy, Jean Paul (author)
- Montreal Neurological Institute & Hospital
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- Pichet Binette, Alexa (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Spreng, R. Nathan (author)
- McGill University,Montreal Neurological Institute & Hospital
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- Descoteaux, Maxime (author)
- Sherbrooke University
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- Villeneuve, Sylvia (author)
- McGill University
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(creator_code:org_t)
- English.
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In: Alzheimer's and Dementia. - 1552-5260.
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks. DISCUSSION: White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties. Highlights: Aβ and tau were associated with longitudinal memory change over ∼7.5 years. White matter properties attenuated the impact of tau pathology on memory change. Health/risk factors were associated with white matter properties.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- amyloid-β
- cognitive resilience
- default mode network
- limbic network
- tau
- white matter
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Qiu, Ting
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Liu, Zhen Qi
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Rheault, Françoi ...
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Legarreta, Jon H ...
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Valcourt Caron, ...
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St-Onge, Frédéri ...
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show more...
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Strikwerda-Brown ...
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Metz, Amelie
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Dadar, Mahsa
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Soucy, Jean Paul
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Pichet Binette, ...
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Spreng, R. Natha ...
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Descoteaux, Maxi ...
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Villeneuve, Sylv ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University