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Integrated Brain At...
Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment
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- Salinas, Casper Bo Gravesen (author)
- Technical University of Denmark
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- Lu, Tess Tsai-Hsiu (author)
- Novo Nordisk A/S
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- Gabery, Sanaz (author)
- Lund University,Lunds universitet,Novo Nordisk A/S
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- Marstal, Kasper (author)
- Erasmus University Medical Center
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- Alanentalo, Tomas (author)
- Novo Nordisk A/S
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- Mercer, Aaron Jeffrey (author)
- Novo Nordisk, Inc., US
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- Cornea, Anda (author)
- Novo Nordisk, Inc., US
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- Conradsen, Knut (author)
- Technical University of Denmark
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- Hecksher-Sørensen, Jacob (author)
- Novo Nordisk A/S
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- Dahl, Anders Bjorholm (author)
- Technical University of Denmark
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- Knudsen, Lotte Bjerre (author)
- Novo Nordisk A/S
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- Secher, Anna (author)
- Novo Nordisk A/S
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(creator_code:org_t)
- 2018-07-09
- 2018
- English 12 s.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
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Abstract
Subject headings
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- Light Sheet Fluorescence Microscopy (LSFM) of whole organs, in particular the brain, offers a plethora of biological data imaged in 3D. This technique is however often hindered by cumbersome non-automated analysis methods. Here we describe an approach to fully automate the analysis by integrating with data from the Allen Institute of Brain Science (AIBS), to provide precise assessment of the distribution and action of peptide-based pharmaceuticals in the brain. To illustrate this approach, we examined the acute central nervous system effects of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide. Peripherally administered liraglutide accessed the hypothalamus and brainstem, and led to activation in several brain regions of which most were intersected by projections from neurons in the lateral parabrachial nucleus. Collectively, we provide a rapid and unbiased analytical framework for LSFM data which enables quantification and exploration based on data from AIBS to support basic and translational discovery.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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Salinas, Casper ...
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Lu, Tess Tsai-Hs ...
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Gabery, Sanaz
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Marstal, Kasper
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Alanentalo, Toma ...
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Mercer, Aaron Je ...
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show more...
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Cornea, Anda
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Conradsen, Knut
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Hecksher-Sørense ...
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Dahl, Anders Bjo ...
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Knudsen, Lotte B ...
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Secher, Anna
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Scientific Repor ...
- By the university
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Lund University