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Sökning: id:"swepub:oai:lup.lub.lu.se:856dd2cb-b811-445d-aa45-ac8569349050" > Periostin Secreted ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003951naa a2200421 4500
001oai:lup.lub.lu.se:856dd2cb-b811-445d-aa45-ac8569349050
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/46562922 URI
0247 a https://doi.org/10.1089/scd.2014.01242 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Noack, Sandra4 aut
2451 0a Periostin Secreted by Mesenchymal Stem Cells Supports Tendon Formation in an Ectopic Mouse Model
264 1b Mary Ann Liebert Inc,c 2014
520 a True tendon regeneration in human patients remains a vision of musculoskeletal therapies. In comparison to other mesenchymal lineages the biology of tenogenic differentiation is barely understood. Specifically, easy and efficient protocols are lacking that might enable tendon cell and tissue differentiation based on adult (stem) cell sources. In the murine mesenchymal progenitor cell line C3H10T1/2 overexpression of the growth factor bone morphogenetic protein 2 (BMP2) and a constitutively active transcription factor, Smad8 L + MH2, mediates tendon cell differentiation in vitro and the formation of tendon-like tissue in vivo. We hypothesized that during this differentiation secreted factors involved in extracellular matrix formation exert a major impact on tendon development. Gene expression analyses revealed four genes encoding secreted factors that are notably upregulated: periostin, C-type lectin domain family 3 (member b), RNase A4, and follistatin-like 1. These factors have not previously been implicated in tendon biology. Among these, periostin showed a specific expression in tenocytes of adult mouse Achilles tendon and in chondrocytes within the nonmineralized fibrocartilage zone of the enthesis with the calcaneus. Overexpression of periostin alone or in combination with constitutively active BMP receptor type in human mesenchymal stem cells and subsequent implantation into ectopic sites in mice demonstrated a reproducible moderate tenogenic capacity that has not been described before. Therefore, periostin may belong to the factors contributing to the development of tenogenic tissue.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Seiffart, Virginia4 aut
7001 a Willbold, Elmar4 aut
7001 a Laggies, Sandra4 aut
7001 a Winkel, Andreas4 aut
7001 a Shahab-Osterloh, Sandra4 aut
7001 a Floerkemeier, Thilo4 aut
7001 a Hertwig, Falku Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-fah
7001 a Steinhoff, Christine4 aut
7001 a Nuber, Ulrikeu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-unu
7001 a Gross, Gerhard4 aut
7001 a Hoffmann, Andrea4 aut
7102 a Stamcellscentrum (SCC)b Avdelningen för stamcellsforskning4 org
7730 t Stem Cells and Developmentd : Mary Ann Liebert Incg 23:16, s. 1844-1857q 23:16<1844-1857x 1557-8534x 1547-3287
8564 u http://dx.doi.org/10.1089/scd.2014.0124y FULLTEXT
8564 u https://europepmc.org/articles/pmc4120815?pdf=render
8564 8u https://lup.lub.lu.se/record/4656292
8564 8u https://doi.org/10.1089/scd.2014.0124

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