Search: id:"swepub:oai:lup.lub.lu.se:85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb" >
Refining the Defini...
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Frohnert, Brigitte I.University of Colorado
(author)
Refining the Definition of Stage 1 Type 1 Diabetes : An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-02
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American Diabetes Association,2023
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9 s.
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LIBRIS-ID:oai:lup.lub.lu.se:85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb
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https://lup.lub.lu.se/record/85a3970c-8fe0-4d31-8b5d-2ee6b2130cebURI
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https://doi.org/10.2337/dc22-1960DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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OBJECTIVE To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddlers enrolled by age 2.5 years and comparison between groups using Kaplan-Meier survival analysis. RESULTS Of 865 (5%) children with mIA, 537 (62%) progressed to type 1 diabetes. The 15-year cumulative incidence of diabetes varied from the most stringent definition (mIA/ Persistent/2: two or more islet autoantibodies positive at the same visit with two or more antibodies persistent at next visit; 88% [95% CI 85–92%]) to the least stringent (mIA/Any: positivity for two islet autoantibodies without co-occurring positivity or persistence; 18% [5–40%]). Progression in mIA/Persistent/2 was significantly higher than all other groups (P < 0.0001). Intermediate stringency definitions showed intermediate risk and were significantly different than mIA/Any (P < 0.05); however, differences waned over the 2-year follow-up among those who did not subsequently reach higher stringency. Among mIA/Persistent/2 individuals with three autoantibodies, loss of one autoantibody by the 2-year follow-up was associated with accelerated progression. Age was significantly associated with time from seroconversion to mIA/ Persistent/2 status and mIA to stage 3 type 1 diabetes. CONCLUSIONS The 15-year risk of progression to type 1 diabetes risk varies markedly from 18 to 88% based on the stringency of mIA definition. While initial categorization identifies highest-risk individuals, short-term follow-up over 2 years may help stratify evolving risk, especially for those with less stringent definitions of mIA.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ghalwash, MohamedAin Shams University,IBM Thomas J. Watson Research Center
(author)
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Li, YingIBM Thomas J. Watson Research Center
(author)
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Ng, KenneyIBM Thomas J. Watson Research Center
(author)
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Dunne, Jessica L.Juvenile Diabetes Research Foundation
(author)
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Lundgren, MarkusLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad(Swepub:lu)med-mn2
(author)
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Hagopian, WilliamPacific Northwest Research Institute
(author)
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Lou, OliviaJuvenile Diabetes Research Foundation
(author)
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Winkler, ChristianeHelmholtz Zentrum München
(author)
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Toppari, JormaTurku University Hospital
(author)
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Veijola, RiittaUniversity of Oulu
(author)
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Anand, VibhaIBM Thomas J. Watson Research Center
(author)
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University of ColoradoAin Shams University
(creator_code:org_t)
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T1DI Study Group
Related titles
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In:Diabetes Care: American Diabetes Association46:10, s. 1753-17610149-59921935-5548
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Frohnert, Brigit ...
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Ghalwash, Mohame ...
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Li, Ying
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Ng, Kenney
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Dunne, Jessica L ...
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Lundgren, Markus
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Hagopian, Willia ...
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Lou, Olivia
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Winkler, Christi ...
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Toppari, Jorma
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Veijola, Riitta
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Anand, Vibha
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes Care
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Lund University