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Search: id:"swepub:oai:lup.lub.lu.se:85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb" > Refining the Defini...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004323naa a2200445 4500
001oai:lup.lub.lu.se:85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb
003SwePub
008231206s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb2 URI
0247 a https://doi.org/10.2337/dc22-19602 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Frohnert, Brigitte I.u University of Colorado4 aut
2451 0a Refining the Definition of Stage 1 Type 1 Diabetes : An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity
264 c 2023-03-02
264 1b American Diabetes Association,c 2023
300 a 9 s.
520 a OBJECTIVE To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddlers enrolled by age 2.5 years and comparison between groups using Kaplan-Meier survival analysis. RESULTS Of 865 (5%) children with mIA, 537 (62%) progressed to type 1 diabetes. The 15-year cumulative incidence of diabetes varied from the most stringent definition (mIA/ Persistent/2: two or more islet autoantibodies positive at the same visit with two or more antibodies persistent at next visit; 88% [95% CI 85–92%]) to the least stringent (mIA/Any: positivity for two islet autoantibodies without co-occurring positivity or persistence; 18% [5–40%]). Progression in mIA/Persistent/2 was significantly higher than all other groups (P < 0.0001). Intermediate stringency definitions showed intermediate risk and were significantly different than mIA/Any (P < 0.05); however, differences waned over the 2-year follow-up among those who did not subsequently reach higher stringency. Among mIA/Persistent/2 individuals with three autoantibodies, loss of one autoantibody by the 2-year follow-up was associated with accelerated progression. Age was significantly associated with time from seroconversion to mIA/ Persistent/2 status and mIA to stage 3 type 1 diabetes. CONCLUSIONS The 15-year risk of progression to type 1 diabetes risk varies markedly from 18 to 88% based on the stringency of mIA definition. While initial categorization identifies highest-risk individuals, short-term follow-up over 2 years may help stratify evolving risk, especially for those with less stringent definitions of mIA.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Ghalwash, Mohamedu Ain Shams University,IBM Thomas J. Watson Research Center4 aut
7001 a Li, Yingu IBM Thomas J. Watson Research Center4 aut
7001 a Ng, Kenneyu IBM Thomas J. Watson Research Center4 aut
7001 a Dunne, Jessica L.u Juvenile Diabetes Research Foundation4 aut
7001 a Lundgren, Markusu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad4 aut0 (Swepub:lu)med-mn2
7001 a Hagopian, Williamu Pacific Northwest Research Institute4 aut
7001 a Lou, Oliviau Juvenile Diabetes Research Foundation4 aut
7001 a Winkler, Christianeu Helmholtz Zentrum München4 aut
7001 a Toppari, Jormau Turku University Hospital4 aut
7001 a Veijola, Riittau University of Oulu4 aut
7001 a Anand, Vibhau IBM Thomas J. Watson Research Center4 aut
7102 a University of Coloradob Ain Shams University4 org
7102 a T1DI Study Group
7730 t Diabetes Cared : American Diabetes Associationg 46:10, s. 1753-1761q 46:10<1753-1761x 0149-5992x 1935-5548
8564 u http://dx.doi.org/10.2337/dc22-1960x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb
8564 8u https://doi.org/10.2337/dc22-1960

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