Search: id:"swepub:oai:lup.lub.lu.se:85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb" > Refining the Defini...
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000 | 04323naa a2200445 4500 | |
001 | oai:lup.lub.lu.se:85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb | |
003 | SwePub | |
008 | 231206s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb2 URI |
024 | 7 | a https://doi.org/10.2337/dc22-19602 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Frohnert, Brigitte I.u University of Colorado4 aut |
245 | 1 0 | a Refining the Definition of Stage 1 Type 1 Diabetes : An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity |
264 | c 2023-03-02 | |
264 | 1 | b American Diabetes Association,c 2023 |
300 | a 9 s. | |
520 | a OBJECTIVE To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddlers enrolled by age 2.5 years and comparison between groups using Kaplan-Meier survival analysis. RESULTS Of 865 (5%) children with mIA, 537 (62%) progressed to type 1 diabetes. The 15-year cumulative incidence of diabetes varied from the most stringent definition (mIA/ Persistent/2: two or more islet autoantibodies positive at the same visit with two or more antibodies persistent at next visit; 88% [95% CI 85–92%]) to the least stringent (mIA/Any: positivity for two islet autoantibodies without co-occurring positivity or persistence; 18% [5–40%]). Progression in mIA/Persistent/2 was significantly higher than all other groups (P < 0.0001). Intermediate stringency definitions showed intermediate risk and were significantly different than mIA/Any (P < 0.05); however, differences waned over the 2-year follow-up among those who did not subsequently reach higher stringency. Among mIA/Persistent/2 individuals with three autoantibodies, loss of one autoantibody by the 2-year follow-up was associated with accelerated progression. Age was significantly associated with time from seroconversion to mIA/ Persistent/2 status and mIA to stage 3 type 1 diabetes. CONCLUSIONS The 15-year risk of progression to type 1 diabetes risk varies markedly from 18 to 88% based on the stringency of mIA definition. While initial categorization identifies highest-risk individuals, short-term follow-up over 2 years may help stratify evolving risk, especially for those with less stringent definitions of mIA. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Ghalwash, Mohamedu Ain Shams University,IBM Thomas J. Watson Research Center4 aut |
700 | 1 | a Li, Yingu IBM Thomas J. Watson Research Center4 aut |
700 | 1 | a Ng, Kenneyu IBM Thomas J. Watson Research Center4 aut |
700 | 1 | a Dunne, Jessica L.u Juvenile Diabetes Research Foundation4 aut |
700 | 1 | a Lundgren, Markusu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad4 aut0 (Swepub:lu)med-mn2 |
700 | 1 | a Hagopian, Williamu Pacific Northwest Research Institute4 aut |
700 | 1 | a Lou, Oliviau Juvenile Diabetes Research Foundation4 aut |
700 | 1 | a Winkler, Christianeu Helmholtz Zentrum München4 aut |
700 | 1 | a Toppari, Jormau Turku University Hospital4 aut |
700 | 1 | a Veijola, Riittau University of Oulu4 aut |
700 | 1 | a Anand, Vibhau IBM Thomas J. Watson Research Center4 aut |
710 | 2 | a University of Coloradob Ain Shams University4 org |
710 | 2 | a T1DI Study Group |
773 | 0 | t Diabetes Cared : American Diabetes Associationg 46:10, s. 1753-1761q 46:10<1753-1761x 0149-5992x 1935-5548 |
856 | 4 | u http://dx.doi.org/10.2337/dc22-1960x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb |
856 | 4 8 | u https://doi.org/10.2337/dc22-1960 |
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