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Quantification of t...
Quantification of the in vivo brain ultrashort-T2* component in healthy volunteers
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- Deveshwar, Nikhil (author)
- University of California, San Francisco,University of California, Berkeley
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- Yao, Jingwen (author)
- University of California, San Francisco
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- Han, Misung (author)
- University of California, San Francisco
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- Dwork, Nicholas (author)
- University of Colorado School of Medicine
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- Shen, Xin (author)
- University of California, San Francisco
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- Ljungberg, Emil (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Caverzasi, Eduardo (author)
- University of California, San Francisco
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- Cao, Peng (author)
- University of Hong Kong
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- Henry, Roland (author)
- University of California, San Francisco
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- Green, Ari (author)
- University of California, San Francisco
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- Larson, Peder E.Z. (author)
- University of California, San Francisco
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(creator_code:org_t)
- English.
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In: Magnetic Resonance in Medicine. - 0740-3194.
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http://dx.doi.org/10...
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Abstract
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- Purpose: Recent work has shown MRI is able to measure and quantify signals of phospholipid membrane-bound protons associated with myelin in the human brain. This work seeks to develop an improved technique for characterizing this brain ultrashort- (Formula presented.) component in vivo accounting for (Formula presented.) weighting. Methods: Data from ultrashort echo time scans from 16 healthy volunteers with variable flip angles (VFA) were collected and fitted into an advanced regression model to quantify signal fraction, relaxation time, and frequency shift of the ultrashort- (Formula presented.) component. Results: The fitted components show intra-subject differences of different white matter structures and significantly elevated ultrashort- (Formula presented.) signal fraction in the corticospinal tracts measured at 0.09 versus 0.06 in other white matter structures and significantly elevated ultrashort- (Formula presented.) frequency shift in the body of the corpus callosum at (Formula presented.) 1.5 versus (Formula presented.) 2.0 ppm in other white matter structures. Conclusion: The significantly different measured components and measured (Formula presented.) relaxation time of the ultrashort- (Formula presented.) component suggest that this method is picking up novel signals from phospholipid membrane-bound protons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- brain imaging
- multicomponent fit model
- myelin
- ultrashort echo time
- UTE
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Deveshwar, Nikhi ...
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Yao, Jingwen
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Han, Misung
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Dwork, Nicholas
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Shen, Xin
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Ljungberg, Emil
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show more...
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Caverzasi, Eduar ...
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Cao, Peng
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Henry, Roland
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Green, Ari
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Larson, Peder E. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Magnetic Resonan ...
- By the university
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Lund University