Search: id:"swepub:oai:lup.lub.lu.se:906d34da-c2c9-45eb-bd1c-aa401b2ae86b" >
The effects and pos...
The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells
-
- Zhou, Ying (author)
- Third Affiliated Hospital of Soochow University
-
- Yao, Shuang (author)
- Third Affiliated Hospital of Soochow University
-
- Yu, Miaomei (author)
- Third Affiliated Hospital of Soochow University
-
show more...
-
- Wei, Jiang (author)
- Third Affiliated Hospital of Soochow University
-
- Fang, Qi (author)
- Third Affiliated Hospital of Soochow University
-
- Xu, Ning (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
-
- Luo, Guanghua (author)
- Third Affiliated Hospital of Soochow University
-
show less...
-
(creator_code:org_t)
- 2021-11-13
- 2022
- English.
-
In: Molecular Biology Reports. - : Springer Science and Business Media LLC. - 0301-4851 .- 1573-4978. ; 49:2, s. 1171-1179
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://www.research...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P < 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P < 0.05), while in MCF-7 cells, VDR levels decreased (P < 0.05). Conclusions: ApoM can partially inhibit the growth of BC cells. VDR may play a role, but is not the main pathway.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Apolipoprotein M
- Biological behavior
- Breast cancer
- Tumor in situ
- Vitamin D receptor
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database