Sökning: id:"swepub:oai:lup.lub.lu.se:928de913-b3be-4801-b4e2-985f4cda91b8" > Aquaglyceroporins a...
Fältnamn | Indikatorer | Metadata |
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000 | 04922naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:928de913-b3be-4801-b4e2-985f4cda91b8 | |
003 | SwePub | |
008 | 211101s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/928de913-b3be-4801-b4e2-985f4cda91b82 URI |
024 | 7 | a https://doi.org/10.1016/j.bbamem.2021.1837952 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Huang, Pengu Lund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups4 aut0 (Swepub:lu)hu8161pe |
245 | 1 0 | a Aquaglyceroporins and orthodox aquaporins in human adipocytes |
264 | 1 | b Elsevier BV,c 2022 |
520 | a Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
653 | a AQP | |
653 | a Aquaglyceroporins | |
653 | a Human adipocytes | |
653 | a Orthodox aquaporins | |
653 | a Perilipin 1 | |
700 | 1 | a Hansen, Jesper S.u Lund University4 aut |
700 | 1 | a Saba, Karim H.u Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Komplexa kromosomförändringar i cancer,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Genetic chaos in aggressive cancer,Lund University Research Groups4 aut0 (Swepub:lu)ka1361sa |
700 | 1 | a Bergman, Annau Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,MLL-rearrangerad leukemi hos spädbarn,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,The pathogenetic mechanisms behind MLL-rearranged acute leukemia in infancy,Lund University Research Groups4 aut0 (Swepub:lu)an8534be |
700 | 1 | a Negoita, Florentinau Lund University,Lunds universitet,Proteinfosforylering,Forskargrupper vid Lunds universitet,Protein Phosphorylation,Lund University Research Groups4 aut0 (Swepub:lu)med-flf |
700 | 1 | a Gourdon, Pontusu Lund University,Lunds universitet,Membranproteinstrukturbiologi,Forskargrupper vid Lunds universitet,Membrane Protein Structural Biology,Lund University Research Groups4 aut0 (Swepub:lu)med-pgd |
700 | 1 | a Hagström-Andersson, Annau Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,MLL-rearrangerad leukemi hos spädbarn,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,The pathogenetic mechanisms behind MLL-rearranged acute leukemia in infancy,Lund University Research Groups4 aut0 (Swepub:lu)kgen-aan |
700 | 1 | a Lindkvist-Petersson, Karinu Lund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups,LINXS - Lund institute of advanced neutron and x-ray science4 aut0 (Swepub:lu)mbfy-kpe |
710 | 2 | a Medicinsk strukturbiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Biochimica et Biophysica Acta - Biomembranesd : Elsevier BVg 1864:1q 1864:1x 0005-2736 |
856 | 4 | u http://dx.doi.org/10.1016/j.bbamem.2021.183795x freey FULLTEXT |
856 | 4 | u https://doi.org/10.1016/j.bbamem.2021.183795 |
856 | 4 8 | u https://lup.lub.lu.se/record/928de913-b3be-4801-b4e2-985f4cda91b8 |
856 | 4 8 | u https://doi.org/10.1016/j.bbamem.2021.183795 |
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