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Genetic variation i...
Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people
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Yang, Zhen (author)
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Wen, Jie (author)
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Tao, Xiaoming (author)
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Lu, Bin (author)
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Du, Yanping (author)
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Wang, Mei (author)
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Wang, Xuanchun (author)
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Zhang, Weiwei (author)
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Gong, Wei (author)
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- Ling, Charlotte (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Wu, Songhua (author)
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Hu, Renming (author)
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(creator_code:org_t)
- 2010-07-13
- 2011
- English.
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In: Molecular Biology Reports. - : Springer Science and Business Media LLC. - 0301-4851 .- 1573-4978. ; 38:2, s. 1145-1150
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P ([dom]) = 7.2 x 10(-3)). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P ([add]) = 3.8 x 10(-4)) and CRP (P ([add]) = 2.9 x 10(-4)) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- GCKR
- Polymorphism
- Non-alcoholic fatty liver disease
- CRP
- Triglyceride
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Yang, Zhen
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Wen, Jie
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Tao, Xiaoming
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Lu, Bin
-
Du, Yanping
-
Wang, Mei
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show more...
-
Wang, Xuanchun
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Zhang, Weiwei
-
Gong, Wei
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Ling, Charlotte
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Wu, Songhua
-
Hu, Renming
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Molecular Biolog ...
- By the university
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Lund University