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International Myelo...
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders
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Dispenzieri, A. (author)
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Kyle, R. (author)
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Merlini, G. (author)
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Miguel, J. S. (author)
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Ludwig, H. (author)
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Hajek, R. (author)
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Palumbo, A. (author)
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Jagannath, S. (author)
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Blade, J. (author)
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Lonial, S. (author)
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Dimopoulos, M. (author)
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Comenzo, R. (author)
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Einsele, H. (author)
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Barlogie, B. (author)
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Anderson, K. (author)
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Gertz, M. (author)
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Harousseau, J. L. (author)
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Attal, M. (author)
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Tosi, P. (author)
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Sonneveld, P. (author)
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Boccadoro, M. (author)
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Morgan, G. (author)
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Richardson, P. (author)
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Sezer, O. (author)
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Mateos, M. V. (author)
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Cavo, M. (author)
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Joshua, D. (author)
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- Turesson, Ingemar (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Chen, W. (author)
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Shimizu, K. (author)
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Powles, R. (author)
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Rajkumar, S. V. (author)
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Durie, B. G. M. (author)
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(creator_code:org_t)
- 2008-11-20
- 2009
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 23:2, s. 215-224
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Abstract
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- The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in combination with serum protein electrophoresis (PEL) and immunofixation yields high sensitivity, and negates the need for 24-h urine studies for diagnoses other than light chain amyloidosis (AL). Second, the baseline FLC measurement is of major prognostic value in virtually every PCD. Third, the FLC assay allows for quantitative monitoring of patients with oligosecretory PCD, including AL, oligosecretory myeloma and nearly two-thirds of patients who had previously been deemed to have non-secretory myeloma. In AL patients, serial FLC measurements outperform PEL and immunofixation. In oligosecretory myeloma patients, although not formally validated, serial FLC measurements reduce the need for frequent bone marrow biopsies. In contrast, there are no data to support using FLC assay in place of 24-h urine PEL for monitoring or for serial measurements in PCD with measurable disease by serum or urine PEL. This paper provides consensus guidelines for the use of this important assay, in the diagnosis and management of clonal PCD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- myeloma
- amyloid
- immunoglobulin-free light chain
- prognosis
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Leukemia
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To the university's database
- By the author/editor
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Dispenzieri, A.
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Kyle, R.
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Merlini, G.
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Miguel, J. S.
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Ludwig, H.
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Hajek, R.
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show more...
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Palumbo, A.
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Jagannath, S.
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Blade, J.
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Lonial, S.
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Dimopoulos, M.
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Comenzo, R.
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Einsele, H.
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Barlogie, B.
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Anderson, K.
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Gertz, M.
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Harousseau, J. L ...
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Attal, M.
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Tosi, P.
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Sonneveld, P.
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Boccadoro, M.
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Morgan, G.
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Richardson, P.
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Sezer, O.
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Mateos, M. V.
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Cavo, M.
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Joshua, D.
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Turesson, Ingema ...
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Chen, W.
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Shimizu, K.
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Powles, R.
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Rajkumar, S. V.
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Durie, B. G. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia
- By the university
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Lund University
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Karolinska Institutet