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The effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors—an experimental study in rats
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- Carlsson, Goran (author)
- Lund University
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- Hafström, Larsolof (author)
- Lund University
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- Hugander, Anders (author)
- Lund University
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- (creator_code:org_t)
- Wiley, 1983
- 1983
- English 4 s.
- In: Journal of Surgical Oncology. - : Wiley. - 0022-4790 .- 1096-9098. ; 22:1, s. 37-40
- Journal article (peer-reviewed)
Abstract
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- The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N‐methyl‐N‐nitroso‐guanidine‐induced adenocarcinoma in the liver. Total body hyperthermia (41.5°C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1 day after HAL, there was a 50% mortality.
Keyword
- hepatic artery ligation
- hyperthermia
- liver tumor
- microwaves
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- art (subject category)
- ref (subject category)
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