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The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila.

Castillejo-Lopez, Casimiro (author)
Lund University,Lunds universitet,Utvecklingsbiologi i invertebrater, Udo Häckers grupp,Forskargrupper vid Lunds universitet,Invertebrate Developmental Biology, Udo Haecker's group,Lund University Research Groups
Häcker, Udo (author)
Lund University,Lunds universitet,Utvecklingsbiologi i invertebrater, Udo Häckers grupp,Forskargrupper vid Lunds universitet,Invertebrate Developmental Biology, Udo Haecker's group,Lund University Research Groups
 (creator_code:org_t)
Elsevier BV, 2005
2005
English.
In: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 338:2, s. 1075-1082
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Serine proteases play a central role in defense against pathogens by regulating processes such as blood clotting, melanization of injured surfaces, and proteolytic activation of signaling pathways involved in innate immunity. Here, we present the functional characterization of the Drosophila serine protease Sp7 (CG3006) by inducible RNA interference. We show that Sp7 is constitutively expressed in blood cells during embryonic and larval stages. Silencing of the gene impairs the melanization reaction upon injury. Our data demonstrate that Sp7 is required for phenoloxidase activation and its activity is restricted to a subclass of blood cells, the crystal cells. Transcriptional up-regulation of Sp7 was observed after clean, septic injury and in flies expressing an activated form of Toll; however, mutations in the Toll or the IMD pathway did not abolish expression of Sp7, indicating the existence of other regulatory pathways and/or independent basal transcription.

Subject headings

NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Keyword

Drosophila
RNAi
Serine protease
Melanization
Phenoloxidase
Wound
Blood cells
Innate immunity

Publication and Content Type

art (subject category)
ref (subject category)

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