id:"swepub:oai:lup.lub.lu.se:9c842e25-e32e-4e36-9e98-d21a6258a250"
Sökning: id:"swepub:oai:lup.lub.lu.se:9c842e25-e32e-4e36-9e98-d21a6258a250" > Supplementation wit...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04418naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:9c842e25-e32e-4e36-9e98-d21a6258a250 | |
| 003 | SwePub | |
| 008 | 160401s2002 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:mau-4266 | |
| 024 | 7 | a https://lup.lub.lu.se/record/3257542 URI |
| 024 | 7 | a https://doi.org/10.1161/01.CIR.0000033589.15413.482 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-42662 URI |
| 040 | a (SwePub)lud (SwePub)mau | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Riserus, U4 aut |
| 245 | 1 0 | a Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein - A potential link to fatty acid-induced insulin resistance |
| 264 | 1 | b Lippincott Williams & Wilkins,c 2002 |
| 520 | a Background-Conjugated linoleic acids (CLAs), a group of fatty acids shown to have beneficial effects in animals, are also used as weight loss supplements. Recently, we reported that the t10c12 CLA-isomer caused insulin resistance in abdominally obese men via unknown mechanisms. The aim of the present study was to examine whether CLA has isomer-specific effects on oxidative stress or inflammatory biomarkers and to investigate the relationship between these factors and induced insulin resistance. Methods and Results-In a double-blind placebo-controlled trial, 60 men with metabolic syndrome were randomized to one of 3 groups receiving t10c12 CLA, a CLA mixture, or placebo for 12 weeks. Insulin sensitivity (euglycemic clamp), serum lipids, in vivo lipid peroxidation (determined as urinary 8-iso-PGF(2alpha) [F2-isoprostanes]), 15-ketodihydro PGF(2alpha) plasma vitamin E, plasma C-reactive protein, tumor necrosis factor-a, and interleukin-6 were assessed before and after treatment. Supplementation with t10c12 CLA markedly increased 8-iso-PGF(2alpha) (578%) and C-reactive protein (110%) compared with placebo (P<0.0001 and P<0.01, respectively) and independent of changes in hyperglycemia or dyslipidemia. The increases in 8-iso-PGF(2alpha), but not in C-reactive protein, were significantly and independently related to aggravated insulin resistance. Oxidative stress was related to increased vitamin E levels, suggesting a compensatory mechanism. Conclusions-t10c12 CLA supplementation increases oxidative stress and inflammatory biomarkers in obese men. The oxidative stress seems closely related to induced insulin resistance, suggesting a link between the fatty acid-induced lipid peroxidation seen in the present study and insulin resistance. These unfavorable effects of t10c12 CLA might be of clinical importance with regard to cardiovascular disease, in consideration of the widespread use of dietary supplements containing this fatty acid. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a inflammation | |
| 653 | a fatty acids | |
| 653 | a insulin | |
| 653 | a free radicals | |
| 653 | a syndrome x | |
| 700 | 1 | a Basu, S4 aut |
| 700 | 1 | a Jovinge, Stefanu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)medf-sjo |
| 700 | 1 | a Nordin Fredrikson, Gunillau Malmö högskola,Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Fakulteten för hälsa och samhälle (HS)4 aut0 (Swepub:mau)hsguno |
| 700 | 1 | a Arnlov, J4 aut |
| 700 | 1 | a Vessby, B4 aut |
| 710 | 2 | a Stamcellscentrum (SCC)b Avdelningen för stamcellsforskning4 org |
| 773 | 0 | t Circulationd : Lippincott Williams & Wilkinsg 106:15, s. 1925-1929q 106:15<1925-1929x 1524-4539x 0009-7322 |
| 856 | 4 | u http://dx.doi.org/10.1161/01.CIR.0000033589.15413.48x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/325754 |
| 856 | 4 8 | u https://doi.org/10.1161/01.CIR.0000033589.15413.48 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4266 |
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