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The use of the R6 t...
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies.
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- Li, Jia-Yi (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Popovic, Natalija (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Brundin, Patrik (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2005
- 2005
- English.
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In: NeuroRx. - : Springer Science and Business Media LLC. - 1545-5343. ; 2:3, s. 64-447
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Abstract
Subject headings
Close
- Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. The first transgenic mouse models, R6/1 and R6/2 lines, were established 8 years ago. The R6/2 mice have been the best characterized and the most widely used model to study pathogenesis of HD and therapeutic interventions. In the present review, we especially focus on the characteristics of R6 transgenic mouse models and, in greater detail, describe the different therapeutic strategies that have been tested in these mice. We also, at the end, critically assess the relevance of the HD mouse models compared with the human disease and discuss how they can be best used in the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Huntington Disease: psychology
- Huntington Disease: therapy
- Mice
- Huntington Disease: pathology
- Behavior
- Animal
- Humans
- Huntington Disease: diet therapy
- Huntington Disease: genetics
- Animals
- Anti-Inflammatory Agents: therapeutic use
- Apoptosis: drug effects
- Brain: pathology
- Disease Models
- Transgenic: physiology
- Protease Inhibitors: therapeutic use
- Protein Folding
- Research Support
- Non-U.S. Gov't
- Tissue Therapy
- Transglutaminases: antagonists & inhibitors
Publication and Content Type
- art (subject category)
- ref (subject category)
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