Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes

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Fältnamn	Indikatorer	Metadata
000		04108naa a2200421 4500
001		oai:lup.lub.lu.se:a3955cc6-c23c-4e2a-aff6-83ac78909427
003		SwePub
008		181005s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/a3955cc6-c23c-4e2a-aff6-83ac789094272 URI
024	7	a https://doi.org/10.1111/ceo.133622 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Krogh Nielsen, Marieu University of Copenhagen,Zealand University Hospital4 aut
245	1 0	a Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes
264		c 2018-08-21
264	1	b Wiley,c 2019
520		a Importance: Geographic atrophy (GA) is a progressing atrophy of the neuroretina with no treatment option. Background: Age-related malfunction of retinal microglia amplifies response towards age-related tissue stress in age-related macular degeneration. Here, we investigated monocyte CD200 expression – the circulating middleman negotiating retinal microglial activity – in a poorly understood subtype of age-related macular degeneration. Design: Prospective case–control study. Participants: Forty-six patients with GA and 26 healthy controls were included. Methods: All participants were subjected to a structured interview and detailed retinal examination. Controls were recruited from patient's spouses accompanying them in the clinic to match the groups best possibly. Participants had no history of immune disorders or cancer, and did not receive any immune-modulating medication. Patients did not have any history or sign of choroidal neovascularization in either eye. Fresh drawn blood was stained with monoclonal antibodies and prepared for flow cytometry to evaluate CD200 expression in monocytes and their functional subsets. Main Outcome Measures: The percentage of CD200+ monocytes in patients and controls. Results: We found that monocytes were more CD200 positive in patients with GA compared to healthy age-matched controls. Then, we explored the potential relationship between CD200 expression and important fundus autofluorescence patterns that predict disease progression. Patients with a high risk of progression (patients with high degree of hyperautofluorescence) had distinctly increased CD200 expression compared to other patients with GA. Conclusions and Relevance: Our data reveals that abnormal monocytic CD200 expression is present in GA, and in particular among those identified as fast progressors.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng
653		a age-related macular degeneration
653		a CD200 membrane glycoprotein
653		a geographic atrophy
653		a microglia
653		a monocytes
700	1	a Subhi, Yousifu Zealand University Hospital,University of Copenhagen4 aut
700	1	a Molbech, Christopher R.u Zealand University Hospital,University of Copenhagen4 aut
700	1	a Falk, Mads K.u Zealand University Hospital4 aut
700	1	a Singh, Amardeepu Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Zealand University Hospital4 aut0 (Swepub:lu)am1005si
700	1	a Nissen, Mogens H.u University of Copenhagen4 aut
700	1	a Sørensen, Torben L.u Zealand University Hospital,University of Copenhagen4 aut
710	2	a University of Copenhagenb Zealand University Hospital4 org
773	0	t Clinical and Experimental Ophthalmologyd : Wileyg 47:1, s. 69-78q 47:1<69-78x 1442-6404
856	4	u http://dx.doi.org/10.1111/ceo.13362y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/a3955cc6-c23c-4e2a-aff6-83ac78909427
856	4 8	u https://doi.org/10.1111/ceo.13362

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Av författaren/redakt...: Krogh Nielsen, M ...; Subhi, Yousif; Molbech, Christo ...; Falk, Mads K.; Singh, Amardeep; Nissen, Mogens H ...; visa fler...; Sørensen, Torben ...; visa färre...

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Av lärosätet: Lunds universitet

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