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High-resolution x-r...
High-resolution x-ray structure of human aquaporin 5
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- Horsefield, Rob, 1977 (author)
- Gothenburg University,University of Gothenburg,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- Nordén, Kristina (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Agemark, Maria (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Backmark, Anna, 1979 (author)
- Chalmers University of Technology,Chalmers tekniska högskola
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- Tornroth-Horsefield, Susanna (author)
- Gothenburg University,University of Gothenburg,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- van Scheltinga, Anke C. Terwisscha (author)
- Max Planck Institute of Biophysics,Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Kvassman, Jan (author)
- University of Kalmar,Linnéuniversitetet,Linnaeus University
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- Kjellbom, Per (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Johanson, Urban (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Neutze, Richard, 1969 (author)
- Gothenburg University,University of Gothenburg,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- Fellert, Maria (author)
- Lunds universitet,Lund University
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(creator_code:org_t)
- 2008-09-09
- 2008
- English.
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In: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 105:36, s. 13327-13332
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Abstract
Subject headings
Close
- Human aquaporin 5 (HsAQP5)facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear. AQP5, like AQP2, is subject to posttranslational regulation by phosphorylation, at which point it is trafficked between intracellular storage compartments and the plasma membrane. Details concerning the molecular mechanism of membrane trafficking are unknown. Here we report the x-ray structure of HsAQP5 to 2.0-angstrom resolution and highlight structural similarities and differences relative to other eukaryotic aquaporins. A lipid occludes the putative central pore, preventing the passage of gas or ions through the center of the tetramer. Multiple consensus phosphorylation sites are observed in the structure and their potential regulatory role is discussed. We postulate that a change in the conformation of the C terminus may arise from the phosphorylation of AQP5 and thereby signal trafficking.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- heterologous overexpression
- crystallography
- water channel protein
- trafficking
- membrane protein
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Horsefield, Rob, ...
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Nordén, Kristina
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Agemark, Maria
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Backmark, Anna, ...
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Tornroth-Horsefi ...
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van Scheltinga, ...
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show more...
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Kvassman, Jan
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Kjellbom, Per
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Johanson, Urban
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Neutze, Richard, ...
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Fellert, Maria
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Proceedings of t ...
- By the university
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Lund University
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Chalmers University of Technology
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University of Gothenburg