High-Performance Hemofiltration via Molecular Sieving and Ultra-Low Friction in Carbon Nanotube Capillary Membranes

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:lup.lub.lu.se:a4f514fd-ae5b-4af5-87ab-2c78b7314f46" > High-Performance He...

1 av 1
Föregående post
Nästa post
Till träfflistan

High-Performance Hemofiltration via Molecular Sieving and Ultra-Low Friction in Carbon Nanotube Capillary Membranes

Cheng, Peifu (författare): Vanderbilt University

Ferrell, Nicholas (författare): Ohio State University

Öberg, Carl M. (författare): Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Njurfysiologi och peritonealdialys,Forskargrupper vid Lunds universitet,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Renal physiology and peritoneal dialysis,Lund University Research Groups

visa fler...

Buchsbaum, Steven F. (författare): Lawrence Livermore National Laboratory

Jue, Melinda L. (författare): Lawrence Livermore National Laboratory

Park, Sei Jin (författare): Lawrence Livermore National Laboratory

Wang, Dan (författare): Ohio State University

Roy, Shuvo (författare): University of California, San Francisco

Fornasiero, Francesco (författare): Lawrence Livermore National Laboratory

Fissell, William H. (författare): Vanderbilt University Medical Center,Vanderbilt University

Kidambi, Piran R. (författare): Vanderbilt University

visa färre...

(creator_code:org_t)

2023
2023
Engelska.
Ingår i: Advanced Functional Materials. - 1616-301X. ; 33:50

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Conventional dialyzer membranes typically comprise of unevenly distributed polydisperse, tortuous, rough pores, embedded in relatively thick ≈20–50 µm polymer layers wherein separation occurs via size exclusion as well as differences in diffusivity of the permeating species. However, transport in such polymeric pores is increasingly hindered as the molecule size approaches the pore dimension, resulting in significant retention of undesirable middle molecules (≥15–60 kDa) and uremic toxins. Enhanced removal of middle molecules is usually accompanied by high albumin loss (≈66 kDa) causing hypoalbuminemia. Here, the scalable bottom-up fabrication of wafer-scale carbon nanotube (CNT) membranes with highly aligned, low-friction, straight-channels/capillaries and narrow pore-diameter distributions (≈0.5–4.5 nm) is demonstrated, to overcome persistent challenges in hemofiltration/hemodialysis. Using fluorescein isothiocyanate (FITC)-Ficoll 70 and albumin in phosphate buffered saline (PBS) as well as in bovine blood plasma, it is shown that CNT membranes can allow for significantly higher hydraulic permeability (more than an order of magnitude when normalized to pore area) than commercial high-flux hemofiltration/hemodialysis membranes (HF 400), as well as greatly enhance removal of middle molecules while maintaining comparable albumin retention. These findings are rationalized via an N-pore transport model that highlights the critical role of molecular flexing and deformation during size-selective transport within nanoscale confinements of the CNTs. The unique transport characteristics of CNTs coupled with size-exclusion and wafer-scale fabrication offer transformative advances for hemofiltration, and the obtained insight into molecular transport can aid advancements in several other bio-systems/applications beyond hemofiltration/hemodialysis.

Ämnesord

NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)

Nyckelord

albumin retention
carbon nanotube membranes
carbon nanotubes
enhanced middle molecule clearance
Ficoll sieving
hemofiltration/hemodialysis
hydraulic permeability

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Advanced Functional Materials (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Cheng, Peifu; Ferrell, Nichola ...; Öberg, Carl M.; Buchsbaum, Steve ...; Jue, Melinda L.; Park, Sei Jin; visa fler...; Wang, Dan; Roy, Shuvo; Fornasiero, Fran ...; Fissell, William ...; Kidambi, Piran R ...; visa färre...

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Kemi; och Fysikalisk kemi

Artiklar i publikationen: Advanced Functio ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se