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Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer
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- Fang, Qi (author)
- Third Affiliated Hospital of Soochow University
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- Wang, Xufen (author)
- Third Affiliated Hospital of Soochow University
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- Luo, Guanghua (author)
- Third Affiliated Hospital of Soochow University
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- Anticancer Research USA Inc. 2017
- 2017
- English 8 s.
- In: Anticancer research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 37:9, s. 4845-4852
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- CXCL8
- Estrogen receptor
- Overall survival
- Progesterone receptor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Fang, Qi
- Wang, Xufen
- Luo, Guanghua
- Yu, Miaomei
- Zhang, Xiaoying
- Xu, Ning
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- By the university
- Lund University
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