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Mapping prostatic m...
Mapping prostatic microscopic anisotropy using linear and spherical b-tensor encoding : A preliminary study
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- Nilsson, Markus (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Multidimensional microstructure imaging,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Eklund, Greta (författare)
- Random Walk Imaging AB
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- Szczepankiewicz, Filip (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Multidimensional microstructure imaging,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Skorpil, Mikael (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Bryskhe, Karin (författare)
- Random Walk Imaging AB
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- Westin, Carl Fredrik (författare)
- Harvard Medical School
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- Lindh, Claes (författare)
- Karolinska Institute
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- Blomqvist, Lennart (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Jäderling, Fredrik (författare)
- Karolinska Institutet,Karolinska Institute,Capio St. Görans Sjukhus,Karolinska University Hospital
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(creator_code:org_t)
- 2021-05-31
- 2021
- Engelska 9 s.
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 86:4, s. 2025-2033
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Abstract
Ämnesord
Stäng
- Purpose: Tensor-valued diffusion encoding provides more specific information than conventional diffusion-weighted imaging (DWI), but has mainly been applied in neuroimaging studies. This study aimed to assess its potential for the imaging of prostate cancer (PCa). Methods: Seventeen patients with histologically proven PCa were enrolled. DWI of the prostate was performed with linear and spherical tensor encoding using a maximal b-value of 1.5 ms/µm2 and a voxel size of 3 × 3 × 4 mm3. The gamma-distribution model was used to estimate the mean diffusivity (MD), the isotropic kurtosis (MKI), and the anisotropic kurtosis (MKA). Regions of interest were placed in MR-defined cancerous tissues, as well as in apparently healthy tissues in the peripheral and transitional zones (PZs and TZs). Results: DWI with linear and spherical encoding yielded different image contrasts at high b-values, which enabled the estimation of MKA and MKI. Compared with healthy tissue (PZs and TZs combined) the cancers displayed a significantly lower MD (P <.05), higher MKI (P < 10−5), and lower MKA (P <.05). Compared with the TZ, tissue in the PZ showed lower MD (P < 10−3) and higher MKA (P < 10−3). No significant differences were found between cancers of different Gleason scores, possibly because of the limited sample size. Conclusion: Tensor-valued diffusion encoding enabled mapping of MKA and MKI in the prostate. The elevated MKI in PCa compared with normal tissues suggests an elevated heterogeneity in the cancers. Increased in-plane resolution could improve tumor delineation in future studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- diffusion-weighted imaging
- heterogeneity
- microscopic anisotropy
- prostate cancer
- tensor-valued diffusion encoding
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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