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Neurologic disorder...
Neurologic disorders in long-term survivors of neuroblastoma–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program
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- Norsker, Filippa Nyboe (author)
- Danish Cancer Society
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- Rechnitzer, Catherine (author)
- Copenhagen University Hospital
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- Andersen, Elisabeth Wreford (author)
- Danish Cancer Society
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- Linnet, Karen Markussen (author)
- Aarhus University Hospital
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- Kenborg, Line (author)
- Danish Cancer Society
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- Holmqvist, Anna Sällfors (author)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
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- Tryggvadottir, Laufey (author)
- University of Iceland,Icelandic Cancer Registry
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- Madanat-Harjuoja, Laura Maria (author)
- Finnish Cancer Registry
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- Øra, Ingrid (author)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Thorarinsdottir, Halldora K. (author)
- National University Hospital of Iceland
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- Vettenranta, Kim (author)
- Hospital for Children and Adolescents, Helsinki
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- Bautz, Andrea (author)
- Danish Cancer Society
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- Schrøder, Henrik (author)
- Aarhus University Hospital
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- Hasle, Henrik (author)
- Aarhus University Hospital
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- Winther, Jeanette Falck (author)
- Danish Cancer Society,Aarhus University Hospital
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(creator_code:org_t)
- 2020
- 2020
- English 7 s.
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In: Acta Oncologica. - 0284-186X. ; 59:2, s. 134-140
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Material and methods: Through population-based cancer registries of four Nordic countries we identified 654 5-year survivors of neuroblastoma (diagnosed 1959–2008) and 133,668 matched population comparisons. We grouped neurologic diagnoses from national hospital registries into 11 main diagnostic categories and 56 disease-specific sub-categories and calculated relative risks (RRs), absolute excess risks (AERs), cumulative incidence and mean cumulative count (MCC). Information on cancer treatment was available for 49% of survivors. Results: A hospital contact for a neurologic disorder was observed in 181 survivors 5 years or more from cancer diagnosis with 59 expected, yielding a RR of 3.1 (95% CI 2.7–3.6) and an AER of 16 per 1,000 person-years (95% CI 12–19). The most frequent disorders included epilepsy, paralytic syndromes, diseases of the eyes and ears and hearing loss. The cumulative incidence of any neurologic disorder was 31% in survivors 20 years after cancer diagnosis with a MCC of 0.5 unique diagnoses. All risks were highest in survivors of high-risk neuroblastoma. Conclusion: Neuroblastoma survivors represent a population with a high risk of developing neurologic disorders. Our results should contribute to improving health care planning and underscores the need for systematic follow-up care of this vulnerable group of survivors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Norsker, Filippa ...
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Rechnitzer, Cath ...
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Andersen, Elisab ...
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Linnet, Karen Ma ...
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Kenborg, Line
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Holmqvist, Anna ...
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show more...
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Tryggvadottir, L ...
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Madanat-Harjuoja ...
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Øra, Ingrid
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Thorarinsdottir, ...
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Vettenranta, Kim
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Bautz, Andrea
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Schrøder, Henrik
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Hasle, Henrik
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Winther, Jeanett ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Acta Oncologica
- By the university
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Lund University