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Influence of donor/...
Influence of donor/recipient sex matching on outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia
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Stern, Martin (author)
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Passweg, Jakob R. (author)
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Locasciulli, Anna (author)
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Socie, Gerard (author)
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Schrezenmeier, Hubert (author)
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- Békássy, Albert (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Fuehrer, Monica (author)
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Hows, Jill (author)
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Korthof, Elisabeth T. (author)
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McCann, Shaun (author)
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Tichelli, Andre (author)
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Zoumbos, Nicholas C. (author)
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Marsh, Judith C. W. (author)
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Bacigalupo, Andrea (author)
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Gratwohl, Alois (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2006
- 2006
- English.
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In: Transplantation. - : Ovid Technologies (Wolters Kluwer Health). - 1534-6080 .- 0041-1337. ; 82:2, s. 218-226
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
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- Background. Increased risk of transplant related mortality in male recipients of female hematopoietic stem cell grafts and in vitro reactivity of lymphocytes against H-Y encoded gene products in females with rejected male grafts have been documented. An increased rejection of male grafts in female recipients is not reported for solid organ or stem cell transplants and the role of H-Y as transplantation antigen has been controversial. Methods. Data from 1481 patients with a hematopoietic stem cell transplant for aplastic anemia reported from 154 centers in 28 countries were analyzed. Outcome was compared between patients with donors of the same or opposite Sex. Results. Survival at 5 years was significantly better in patients with donors from the same sex: 68% vs. 60% (P=0.001). Male patients with female donors had a decreased survival (relative risk of death 1.52, P < 0.001) and an increased risk of severe graft-versus-host disease (relative risk 1.33, P=0.03) compared to recipients of sex-matched grafts. Female patients with male donors had a decreased survival (relative risk of death 1.44, P=0.01) and an increased risk of rejection (relative risk 2.20, P=0.01) compared to recipients of sex-matched grafts. In a subgroup analysis, the negative effects of donor/recipient sex-mismatching appeared confined to patients receiving conditioning regimens not containing antithymocyte globulin. Conclusions. These data confirm H-Y as a clinically relevant transplantation antigen, in both the graft-versus-host and the host-versus-graft direction. Wherever possible, donor-recipient sex-matching should be integrated into donor selection algorithms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- graft-versus-host disease
- histocompatibility antigens
- minor
- severe aplastic anemia
- hematopoietic stem cell transplantation
- graft rejection
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Stern, Martin
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Passweg, Jakob R ...
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Locasciulli, Ann ...
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Socie, Gerard
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Schrezenmeier, H ...
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Békássy, Albert
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show more...
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Fuehrer, Monica
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Hows, Jill
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Korthof, Elisabe ...
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McCann, Shaun
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Tichelli, Andre
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Zoumbos, Nichola ...
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Marsh, Judith C. ...
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Bacigalupo, Andr ...
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Gratwohl, Alois
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Transplantation
- By the university
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Lund University