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Sökning: id:"swepub:oai:lup.lub.lu.se:b6594069-6d88-46cd-acbb-66b9dd137db5" > Phylogenetic Patter...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003475naa a2200385 4500
001oai:lup.lub.lu.se:b6594069-6d88-46cd-acbb-66b9dd137db5
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/41580202 URI
0247 a https://doi.org/10.1128/JVI.02075-132 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Henquell, Cecile4 aut
2451 0a Phylogenetic Patterns of Human Coxsackievirus B5 Arise from Population Dynamics between Two Genogroups and Reveal Evolutionary Factors of Molecular Adaptation and Transmission
264 1c 2013
520 a The aim of this study was to gain insights into the tempo and mode of the evolutionary processes that sustain genetic diversity in coxsackievirus B5 (CVB5) and into the interplay with virus transmission. We estimated phylodynamic patterns with a large sample of virus strains collected in Europe by Bayesian statistical methods, reconstructed the ancestral states of genealogical nodes, and tested for selection. The genealogies estimated with the structural one-dimensional gene encoding the VP1 protein and nonstructural 3CD locus allowed the precise description of lineages over time and cocirculating virus populations within the two CVB5 clades, genogroups A and B. Strong negative selection shaped the evolution of both loci, but compelling phylogenetic data suggested that immune selection pressure resulted in the emergence of the two genogroups with opposed evolutionary pathways. The genogroups also differed in the temporal occurrence of the amino acid changes. The virus strains of genogroup A were characterized by sequential acquisition of nonsynonymous changes in residues exposed at the virus 5-fold axis. The genogroup B viruses were marked by selection of three changes in a different domain (VP1 C terminus) during its early emergence. These external changes resulted in a selective sweep, which was followed by an evolutionary stasis that is still ongoing after 50 years. The inferred population history of CVB5 showed an alternation of the prevailing genogroup during meningitis epidemics across Europe and is interpreted to be a consequence of partial cross-immunity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
7001 a Mirand, Audrey4 aut
7001 a Richter, Jan4 aut
7001 a Schuffenecker, Isabelle4 aut
7001 a Böttiger, Blendau Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-bdb
7001 a Diedrich, Sabine4 aut
7001 a Terletskaia-Ladwig, Elena4 aut
7001 a Christodoulou, Christina4 aut
7001 a Peigue-Lafeuille, Helene4 aut
7001 a Bailly, Jean-Luc4 aut
7102 a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Virologyg 87:22, s. 12249-12259q 87:22<12249-12259x 1098-5514
8564 u http://dx.doi.org/10.1128/JVI.02075-13y FULLTEXT
8564 8u https://lup.lub.lu.se/record/4158020
8564 8u https://doi.org/10.1128/JVI.02075-13

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