id:"swepub:oai:lup.lub.lu.se:baf47c22-57f0-4d04-aef1-1654906bba61"
Search: id:"swepub:oai:lup.lub.lu.se:baf47c22-57f0-4d04-aef1-1654906bba61" > Polyamines and micr...
- 1 of 1
- Previous record
- Next record
- To hitlist
Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy
-
- Forte, Amalia (author)
- University of Campania Luigi Vanvitelli
-
- Balistreri, Carmela Rita (author)
- University of Palermo
-
- De Feo, Marisa (author)
- University of Campania Luigi Vanvitelli
- show more...
- show less...
- (creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English 9 s.
- In: Journal of Molecular and Cellular Cardiology. - : Elsevier BV. - 0022-2828. ; 129, s. 179-187
- Research review (peer-reviewed)
Abstract
Subject headings
Close
- Polyamines are small aliphatic cationic molecules synthesized via a highly regulated pathway and involved in general molecular and cellular phenomena. Both mammalian cells and microorganisms synthesize polyamines, and both sources may contribute to the presence of polyamines in the circulation. The dominant location for microorganisms within the body is the gut. Accordingly, the gut microbiota probably synthesizes most of the polyamines in the circulation in addition to those produced by the mammalian host cells. Polyamines are mandatory for cellular growth and proliferation. Established evidence suggests that the polyamine spermidine prolongs lifespan and improves cardiovascular health in animal models and humans through both local mechanisms, involving improved cardiomyocyte function, and systemic mechanisms, including increased NO bioavailability and reduced systemic inflammation. Higher levels of polyamines have been detected in non-dilated aorta of patients affected by bicuspid aortic valve congenital malformation, an aortopathy associated with an increased risk for thoracic ascending aorta aneurysm. In this review, we discuss metabolism of polyamines and their potential effects on vascular smooth muscle and endothelial cell function in vascular pathology of the thoracic ascending aorta associated with bicuspid or tricuspid aortic valve.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
- Journal of Molecular and Cellular Cardiology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Forte, Amalia
- Balistreri, Carm ...
- De Feo, Marisa
- Della Corte, Ale ...
- Hellstrand, Per
- Persson, Lo
- show more...
- Nilsson, Bengt O ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Journal of Molec ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
