id:"swepub:oai:lup.lub.lu.se:bce674af-efbc-4550-b6eb-c71c1b838d45"
Search: id:"swepub:oai:lup.lub.lu.se:bce674af-efbc-4550-b6eb-c71c1b838d45" > Discoidal HDL and a...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03657naa a2200349 4500 | |
| 001 | oai:lup.lub.lu.se:bce674af-efbc-4550-b6eb-c71c1b838d45 | |
| 003 | SwePub | |
| 008 | 160401s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/36284342 URI |
| 024 | 7 | a https://doi.org/10.1194/jlr.M0329042 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Dalla-Riva, Jonathanu Lund University,Lunds universitet,Medicinsk proteinvetenskap,Forskargrupper vid Lunds universitet,Medical Protein Science,Lund University Research Groups4 aut0 (Swepub:lu)med-jd- |
| 245 | 1 0 | a Discoidal HDL and apoA-I-derived peptides improve glucose uptake in skeletal muscle. |
| 264 | 1 | c 2013 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Lipid-free apoA-I and mature spherical HDL have been shown to induce glucose uptake in skeletal muscle. To exploit apoA-I and HDL states for diabetes therapy, further understanding of interaction between muscle and apoA-I is required. This study has examined if nascent discoidal HDL, in which apoA-I attains a different conformation from mature HDL and lipid-free states, could induce muscle glucose uptake and if a specific domain of apoA-I can mediate this effect. Using L6 myotubes stimulated with synthetic reconstituted discoidal HDL (rHDL), we show a glucose uptake effect comparable to insulin. Increased plasma membrane GLUT4 levels in ex vivo rHDL-stimulated myofibers from HA-GLUT4-GFP transgenic mice support this observation. rHDL increased phosphorylation of AMP kinase (AMPK) and acetyl-coA carboxylase (ACC) but not Akt. A survey of domain specific peptides of apoA-I showed that the lipid-free C-terminal 190-243 fragment increases plasma membrane GLUT4, promotes glucose uptake, and activates AMPK signaling but not Akt. This may be explained by changes in α-helical content of 190-243 fragment versus full-length lipid-free apoA-I as assessed by circular dichroism spectroscopy. JLR Discoidal HDL and the 190-243 peptide of apoA-I are potent agonists of glucose uptake in skeletal muscle and the C-terminal α-helical content of apoA-I may be an important determinant of this effect. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 700 | 1 | a Stenkula, Karinu Lund University,Lunds universitet,Medicinsk proteinvetenskap,Forskargrupper vid Lunds universitet,Medical Protein Science,Lund University Research Groups4 aut0 (Swepub:lu)med-ksu |
| 700 | 1 | a Petrlova, Jitkau Lund University,Lunds universitet,Medicinsk proteinvetenskap,Forskargrupper vid Lunds universitet,Medical Protein Science,Lund University Research Groups4 aut0 (Swepub:lu)med-jkp |
| 700 | 1 | a Lagerstedt, Jensu Lund University,Lunds universitet,Medicinsk proteinvetenskap,Forskargrupper vid Lunds universitet,Medical Protein Science,Lund University Research Groups4 aut0 (Swepub:lu)med-jls |
| 710 | 2 | a Medicinsk proteinvetenskapb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Lipid Researchg 54:5, s. 1275-1282q 54:5<1275-1282x 1539-7262 |
| 856 | 4 | u https://portal.research.lu.se/files/2057591/3865460.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/23471027?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1194/jlr.M032904y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3628434 |
| 856 | 4 8 | u https://doi.org/10.1194/jlr.M032904 |
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