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Disease-specific ho...
Disease-specific hospitalizations among 5-year survivors of Wilms tumor : A Nordic population-based cohort study
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- Høgsholt, Stine (author)
- Aarhus University Hospital,Danish Cancer Society
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- Asdahl, Peter Haubjerg (author)
- Aarhus University Hospital,Danish Cancer Society
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- Bonnesen, Trine Gade (author)
- Aarhus University Hospital,Danish Cancer Society
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- Holmqvist, Anna Sällfors (author)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Madanat-Harjuoja, Laura (author)
- Helsinki University Central Hospital,Finnish Cancer Registry,University of Helsinki
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- Tryggvadottir, Laufey (author)
- Icelandic Cancer Registry,University of Iceland
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- Bautz, Andrea (author)
- Danish Cancer Society
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- Albieri, Vanna (author)
- Danish Cancer Society
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- Green, Daniel (author)
- St Jude Children´s Research Hospital, Memphis
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- Winther, Jeanette Falck (author)
- Aarhus University,Danish Cancer Society
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- Hasle, Henrik (author)
- Aarhus University Hospital
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(creator_code:org_t)
- 2021-01-23
- 2021
- English.
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In: Pediatric Blood and Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 68:5
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http://dx.doi.org/10...
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Abstract
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- Background: With modern therapy, over 90% of Wilms tumor patients can expect to become long-term survivors, and focus on morbidity and late effects become increasingly important. We provide a novel evaluation and insight to subsequent hospitalizations in 5-year survivors of Wilms tumor. Methods: As part of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study, we identified 5-year survivors of Wilms tumor. Based on stratified random sampling, we constructed a population comparison cohort. Outcomes of interest were overall hospitalizations; hospitalizations for specific organ systems and disease-specific categories. Standardized hospitalization rate ratios (SHRR) and absolute excess risks (AER) were calculated. Results: We included 913, 5-year survivors of Wilms tumor and 152 231 population comparisons. Survivors of Wilms tumor had an increased overall risk of being hospitalized (SHRR 1.8; 95% confidence interval (CI) 1.7-2.0). The hospitalization risk was increased within all major organ systems: urinary and genital organs (SHRR 2.5; 95% CI 2.1-3.0), endocrine (SHRR 2.5; 95% CI 1.9-3.3), cardiovascular (SHRR 2.2; 95% CI 1.7-2.9), and gastrointestinal (SHRR 1.5; 95% CI 1.3-1.8). Risks for specific diseases are reported in the study. Conclusions: Survivors of Wilms tumor had higher risks than population comparisons for a wide range of diseases, with the highest risks seen for urinary, endocrine, and cardiovascular disorders. Five to 20 years after the Wilms tumor diagnosis, 43% of survivors had been hospitalized at least once versus 29% of population comparisons. The overall AER was 2.3, which translates into 0.2 extra hospitalizations in 10 years for every Wilms tumor survivor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- hospitalization
- late effects
- morbidity
- survivorship
- Wilms tumor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Høgsholt, Stine
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Asdahl, Peter Ha ...
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Bonnesen, Trine ...
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Holmqvist, Anna ...
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Madanat-Harjuoja ...
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Tryggvadottir, L ...
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show more...
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Bautz, Andrea
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Albieri, Vanna
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Green, Daniel
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Winther, Jeanett ...
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Hasle, Henrik
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Pediatric Blood ...
- By the university
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Lund University