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Biphasic blood pressure response to neuropeptide Y in anesthetized rats
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- Grundemar, L (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Wahlestedt, C (author)
- Cornell University
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- Shen, G H (author)
- Georgetown University
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- (creator_code:org_t)
- Elsevier BV, 1990
- 1990
- English.
- In: European Journal of Pharmacology. - : Elsevier BV. - 0014-2999. ; 179:1-2, s. 83-87
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The effects of neuropeptide Y (NPY) on systemic arterial blood pressure and heart rate were studied in anesthetized intact and pithed rats. I.v. doses of NPY (0.3-30 nmol/kg) raised the mean arterial blood pressure dose dependently. At doses of greater than or equal to 3.0 nmol/kg, the initial pressor response was followed by a dose-dependent fall in blood pressure in intact and pithed rats. The depressor response was accompanied 1-2 min after the NPY injection by a slight increase in heart rate in pithed rats but not in intact rats, and 10 min after the injection by a decrease in heart rate in intact rats. After repeated injections of NPY, the depressor effect vanished, whereas the integrated pressor response over time was markedly enhanced. After pretreatment with the histamine H1-receptor antagonist, mepyramine, or with the histamine liberator, compound 48/80, the pressor response to NPY remained but the depressor response disappeared. We suggest that the marked fall in blood pressure can be attributed to NPY-evoked histamine release from mast cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Anesthesia
- Animals
- Blood Pressure/drug effects
- Decerebrate State
- Heart Rate/drug effects
- Injections, Intravenous
- Male
- Neuropeptide Y/administration & dosage
- Pyrilamine/pharmacology
- Rats
- Rats, Inbred Strains
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Grundemar, L
- Wahlestedt, C
- Shen, G H
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- Håkanson, R
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- Lund University
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