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Four evolutionary t...
Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer
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- Karlsson, Jenny (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Valind, Anders (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Holmquist Mengelbier, Linda (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Bredin, Sofia (author)
- Lund University,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Cornmark, Louise (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Jansson, Caroline (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Wali, Amina (author)
- Lund University,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden
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- Viklund, Björn (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Øra, Ingrid (author)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Div Pediat Oncol, Dept Clin Sci, Lund, Sweden
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- Börjesson, Anna (author)
- Lund University,Lunds universitet,Barnkirurgi,Forskargrupper vid Lunds universitet,Pediatric surgery,Lund University Research Groups,Lund Univ, Div Pediat Surg, Dept Clin Sci, Lund, Sweden
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- Backman, Torbjörn (author)
- Lund University,Lunds universitet,Barnkirurgi,Forskargrupper vid Lunds universitet,Pediatric surgery,Lund University Research Groups,Lund Univ, Div Pediat Surg, Dept Clin Sci, Lund, Sweden
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- Braekeveldt, Noémie (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Translat Canc Res, Dept Lab Med, Lund, Sweden
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- Sandstedt, Bengt (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Childhood Canc Res Unit, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Inst, Div Pediat Oncol, Stockholm, Sweden
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- Pal, Niklas (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Childhood Canc Res Unit, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Inst, Div Pediat Oncol, Stockholm, Sweden
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- Isaksson, Anders (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Lackner, Barbara Gürtl (author)
- Med Serv Skane, Dept Pathol, Lab Med, Lund, Sweden
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- Jonson, Tord (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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- Bexell, Daniel (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Translat Canc Res, Dept Lab Med, Lund, Sweden
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- Gisselsson, David (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Cancercellers evolution,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Clinical Genetics,Department of Laboratory Medicine,Pathways of cancer cell evolution,Lund University Research Groups,Lund Univ, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden;Med Serv Skane, Dept Pathol, Lab Med, Lund, Sweden;Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
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(creator_code:org_t)
- 2018-06-04
- 2018
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:7, s. 944-950
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Abstract
Subject headings
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- A major challenge to personalized oncology is that driver mutations vary among cancer cells inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian evolution in different tumor regions has remained unexplored1–5. We mapped the prevalence of genetically distinct clones over 250 regions in 54 childhood cancers. This showed that primary tumors can simultaneously follow up to four evolutionary trajectories over different anatomic areas. The most common pattern consists of subclones with very few mutations confined to a single tumor region. The second most common is a stable coexistence, over vast areas, of clones characterized by changes in chromosome numbers. This is contrasted by a third, less frequent, pattern where a clone with driver mutations or structural chromosome rearrangements emerges through a clonal sweep to dominate an anatomical region. The fourth and rarest pattern is the local emergence of a myriad of clones with TP53 inactivation. Death from disease was limited to tumors exhibiting the two last, most dynamic patterns.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Karlsson, Jenny
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Valind, Anders
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Holmquist Mengel ...
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Bredin, Sofia
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Cornmark, Louise
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Jansson, Carolin ...
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show more...
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Wali, Amina
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Staaf, Johan
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Viklund, Björn
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Øra, Ingrid
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Börjesson, Anna
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Backman, Torbjör ...
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Braekeveldt, Noé ...
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Sandstedt, Bengt
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Pal, Niklas
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Isaksson, Anders
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Lackner, Barbara ...
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Jonson, Tord
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Bexell, Daniel
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Gisselsson, Davi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Uppsala University
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Karolinska Institutet