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Understanding diabe...
Understanding diabetes heterogeneity : key steps towards precision medicine in diabetes
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- Leslie, Richard David (author)
- Queen Mary University
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- Ma, Ronald Ching Wan (author)
- Prince of Wales Hospital Hong Kong,Chinese University of Hong Kong
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University,Novo Nordisk Foundation
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- Nadeau, Kristen J. (author)
- University of Colorado
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- Pearson, Ewan R. (author)
- University of Dundee
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- Redondo, Maria Jose (author)
- Baylor College of Medicine
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(creator_code:org_t)
- 2023
- 2023
- English 13 s.
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In: The Lancet Diabetes and Endocrinology. - 2213-8587. ; 11:11, s. 848-860
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Abstract
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- Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three disease models across all forms of diabetes, namely, the palette model, the threshold model and the gradient model. Once diabetes has developed, further worsening of established diabetes and the subsequent emergence of diabetes complications are kept in check by multiple processes designed to prevent or circumvent metabolic dysfunction. The impact of any given disease risk factor will vary from person-to-person depending on their background, diabetes-related propensity, and environmental exposures. Defining the consequent heterogeneity within diabetes through precision medicine, both in terms of diabetes risk and risk of complications, could improve health outcomes today and shine a light on avenues for novel therapy in the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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