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Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.

Abou, Diane S (author)
Johns Hopkins University
Ulmert, David (author)
Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Memorial Sloan-Kettering Cancer Center
Doucet, Michele (author)
Johns Hopkins University
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Hobbs, Robert F (author)
Johns Hopkins University
Riddle, Ryan C (author)
Johns Hopkins University
Thorek, Daniel L J (author)
Johns Hopkins University
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 (creator_code:org_t)
2015-12-18
2016
English.
In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 108:5
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and efficacy, yet questions remain regarding pharmacodynamics and dosing for optimized patient benefit.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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