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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04538naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:cff4d385-d9a8-4e9d-8d87-0d2831e04750 | |
| 003 | SwePub | |
| 008 | 160404s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/20078922 URI |
| 024 | 7 | a https://doi.org/10.1159/0003291312 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Calvén, Jennyu Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups4 aut0 (Swepub:lu)med-jca |
| 245 | 1 0 | a Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases. |
| 264 | c 2011-06-20 | |
| 264 | 1 | b S. Karger AG,c 2012 |
| 520 | a Background: Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD) exacerbations exhibit TH(2)-like inflammation. We hypothesized that RV-infected bronchial epithelial cells (BEC) overproduce TH(2)-switching hub cytokine, thymic stromal lymphopoietin (TSLP) in COPD. Methods: Primary BEC from healthy (HBEC) and from COPD donors (COPD-BEC) were grown in 12-well plates, infected with RV16 (0.5-5 MOI) or stimulated with agonists for either toll-like receptor (TLR) 3 (dsRNA, 0.1-10 μg/ml) or RIG-I-like helicases (dsRNA-LyoVec, 0.1-10 μg/ml). Cytokine mRNA and protein were determined (RTqPCR; ELISA). Results: dsRNA dose-dependently evoked cytokine gene overproduction of TSLP, CXCL8 and TNF-α in COPD-BEC compared to HBEC. This was confirmed using RV16 infection. IFN-β induction did not differ between COPD-BEC and HBEC. Endosomal TLR3 inhibition by chloroquine dose-dependently inhibited dsRNA-induced TSLP generation and reduced generation of CXCL8, TNF-α, and IFN-β. Stimulation of cytosolic viral sensors (RIG-I-like helicases) with dsRNA-LyoVec increased production of CXCL8, TNF-α, and IFN-β, but not TSLP. Conclusions: Endosomal TLR3-stimulation, by dsRNA or RV16, induces overproduction of TSLP in COPD-BEC. dsRNA- and RV-induced overproduction of TNF-α and CXCL8 involves endosomal TLR3 and cytosolic RIG-I-like helicases and so does the generation of IFN-β in COPD-BEC. RV16 and dsRNA-induced epithelial TSLP may contribute to pathogenic effects at exacerbations and development of COPD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 700 | 1 | a Yudina, Yulyanau Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups4 aut0 (Swepub:lu)med-yyi |
| 700 | 1 | a Hallgren, Oskaru Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lung Biology,Lund University Research Groups,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mmb-oha |
| 700 | 1 | a Westergren-Thorsson, Gunillau Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups4 aut0 (Swepub:lu)medk-gwt |
| 700 | 1 | a Davies, Donna E4 aut |
| 700 | 1 | a Brandelius, Angelicau Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups4 aut0 (Swepub:lu)an2703br |
| 700 | 1 | a Uller, Lenau Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-lul |
| 710 | 2 | a Respiratorisk immunofarmakologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Innate Immunityd : S. Karger AGg 4, s. 86-99q 4<86-99x 1662-811Xx 1662-8128 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/21691053?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1159/000329131y FULLTEXT |
| 856 | 4 | u https://www.karger.com/Article/Pdf/329131 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2007892 |
| 856 | 4 8 | u https://doi.org/10.1159/000329131 |
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