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FLT3 mutations conf...
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
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Lee, Benjamin H. (author)
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Tothova, Zuzana (author)
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Levine, Ross L. (author)
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- Anderson, Kristina (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Buza-Vidas, Natalija (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Cullen, Dana E. (author)
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McDowell, Elizabeth P. (author)
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Adelsperger, Jennifer (author)
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Frhling, Stefan (author)
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Huntly, Brian J. P. (author)
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Beran, Miloslav (author)
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- Jacobsen, Sten Eirik W (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Gilliland, D. Gary (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 12:4, s. 367-380
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Abstract
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- Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Lee, Benjamin H.
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Tothova, Zuzana
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Levine, Ross L.
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Anderson, Kristi ...
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Buza-Vidas, Nata ...
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Cullen, Dana E.
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show more...
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McDowell, Elizab ...
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Adelsperger, Jen ...
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Frhling, Stefan
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Huntly, Brian J. ...
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Beran, Miloslav
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Jacobsen, Sten E ...
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Gilliland, D. Ga ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Cell
- By the university
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Lund University