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Simplicity at the c...
Simplicity at the cost of predictive accuracy in diffuse large B-cell lymphoma : A critical assessment of the R-IPI, IPI, and NCCN-IPI
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- Biccler, Jorne (author)
- Aalborg University
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- Eloranta, Sandra (author)
- Karolinska Institutet,Karolinska Institute
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- de Nully Brown, Peter (author)
- Copenhagen University Hospital
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- Frederiksen, Henrik (author)
- Odense University Hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,Lymphoma - Clinical Research,Lund University Research Groups
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- Smedby, Karin E. (author)
- Karolinska Institutet
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- Bøgsted, Martin (author)
- Aalborg University
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- El-Galaly, Tarec C. (author)
- Aalborg University
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(creator_code:org_t)
- 2017-12-13
- 2018
- English.
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In: Cancer Medicine. - : Wiley. - 2045-7634. ; 7:1, s. 114-122
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Abstract
Subject headings
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- The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI) to a Cox proportional hazards (CPH) model using the same covariates in nondichotomized form. All models were tested in 4863 newly diagnosed DLBCL patients from population-based Nordic registers. The CPH model led to a substantial increase in predictive accuracy as compared to conventional prognostic scores when evaluated by the area under the curve and other relevant tests. Furthermore, the generation of patient-specific survival curves rather than assigning patients to one of few predefined risk groups is a relevant step toward personalized management and treatment. A test-version is available on lymphomapredictor.org.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- IPI
- Diffuse large B-cell lymphoma
- Prognosis
- Prognostic factors
- Risk modeling
Publication and Content Type
- art (subject category)
- ref (subject category)
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