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Hormone-sensitive l...
Hormone-sensitive lipase is not required for cholesteryl ester hydrolysis in macrophages.
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- Contreras, Juan Antonio (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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(creator_code:org_t)
- Elsevier BV, 2002
- 2002
- English.
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In: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 292:4, s. 900-903
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Abstract
Subject headings
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- Storage of cholesteryl esters in the cytoplasm of macrophages is one of the earliest and most ubiquitous event observed in the development of arteriosclerosis. Macrophages have an enormous capacity to uptake and store cholesterol in the form of cytosolic cholesteryl ester droplets. These stores are mobilized by the action of a neutral cholesteryl ester hydrolase (NCEH), producing free cholesterol that is either secreted to extracellular acceptors or reesterified. It has been proposed that hormone-sensitive lipase (HSL) is responsible for the NCEH activity in macrophages. The present work shows, however, that peritoneal macrophages from HSL null mice hydrolyze cytosolic stores of cholesteryl esters at a comparable rate to that of peritoneal macrophages from wild-type mice, therefore demonstrating that HSL is not the main NCEH in macrophages.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Cholesterol Esterase : metabolism
- Cholesterol Esterase : genetics
- Cholesterol Esterase : deficiency
- Cultured
- Cells
- Bucladesine : pharmacology
- Western
- Blotting
- Arteriosclerosis : metabolism
- Animal
- Adipose Tissue : enzymology
- Peritoneal : metabolism
- Mice
- Inbred Strains
- Knockout
- Cholesterol Esters : metabolism
- Cytoplasm : metabolism
- Hydrolysis
- Macrophages
- Peritoneal : drug effects
Publication and Content Type
- art (subject category)
- ref (subject category)
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