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Strategies to desig...
Strategies to design clinical studies to identify predictive biomarkers in cancer research
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- Perez-Gracia, Jose Luis (author)
- University Clinic of Navarra,Health Research Institute of Navarra (IDISNA)
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- Sanmamed, Miguel F. (author)
- Yale University
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- Bosch Campos, Ana (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylära behandlingsstrategier vid bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular therapeutics in breast cancer,Lund University Research Groups
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- Patiño-Garcia, Ana (author)
- Health Research Institute of Navarra (IDISNA),University Clinic of Navarra
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- Schalper, Kurt A. (author)
- Yale University
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- Segura, Victor (author)
- University of Navarra
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- Bellmunt, Joaquim (author)
- Dana-Farber Cancer Institute
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- Tabernero, Josep (author)
- Vall d'Hebron University Hospital
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- Sweeney, Christopher J. (author)
- Dana-Farber Cancer Institute
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- Choueiri, Toni K. (author)
- Dana-Farber Cancer Institute
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- Martín, Miguel (author)
- Complutense University of Madrid
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- Fusco, Juan Pablo (author)
- University Clinic of Navarra
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- Rodriguez-Ruiz, Maria Esperanza (author)
- University of Navarra
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- Calvo, Alfonso (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra
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- Prior, Celia (author)
- University of Navarra
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- Paz-Ares, Luis (author)
- 12 de Octubre University Hospital
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- Pio, Ruben (author)
- University of Navarra,Health Research Institute of Navarra (IDISNA)
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- Gonzalez-Billalabeitia, Enrique (author)
- Hospital General Universitario Morales Meseguer
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- Gonzalez Hernandez, Alvaro (author)
- University Clinic of Navarra
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- Páez, David (author)
- Hospital de Sant Pau
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- Piulats, Jose María (author)
- Catalan Institute of Oncology
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- Gurpide, Alfonso (author)
- Health Research Institute of Navarra (IDISNA)
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- Andueza, Mapi (author)
- University Clinic of Navarra
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- Velasco, Guillermo (author)
- Dana-Farber Cancer Institute
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- Pazo, Roberto (author)
- Miguel Servet University Hospital
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- Grande, Enrique (author)
- Hospital Ramón Y Cajal
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- Nicolas, Pilar (author)
- University of the Basque Country
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- Abad-Santos, Francisco (author)
- Hospital Universitario de la Princesa
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- Garcia-Donas, Jesus (author)
- Autonomous University of Madrid
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- Castellano, Daniel (author)
- 12 de Octubre University Hospital
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- Pajares, María J. (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra
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- Suarez, Cristina (author)
- Vall d'Hebron University Hospital
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- Colomer, Ramon (author)
- Hospital Universitario de la Princesa
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- Montuenga, Luis M. (author)
- University of Navarra,Health Research Institute of Navarra (IDISNA)
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- Melero, Ignacio (author)
- University Clinic of Navarra,University of Navarra,Health Research Institute of Navarra (IDISNA)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Cancer Treatment Reviews. - : Elsevier BV. - 0305-7372. ; 53, s. 79-97
- Related links:
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http://dx.doi.org/10... (free)
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http://www.cancertre...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promising targets and are seldom validated. The lack of a proper methodology also determines that many anti-cancer drugs are developed below their potential, due to failure to identify predictive biomarkers. While some drugs will be systematically administered to many patients who will not benefit from them, leading to unnecessary toxicities and costs, others will never reach registration due to our inability to identify the specific patient population in which they are active. Despite these drawbacks, a limited number of outstanding predictive biomarkers have been successfully identified and validated, and have changed the standard practice of oncology. In this manuscript, a multidisciplinary panel reviews how those key biomarkers were identified and, based on those experiences, proposes a methodological framework—the DESIGN guidelines—to standardize the clinical design of biomarker identification studies and to develop future research in this pivotal field.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Biomarkers
- Clinical trial design
- Extreme phenotypes
- Mutation
- Rearrangement
Publication and Content Type
- for (subject category)
- ref (subject category)
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Perez-Gracia, Jo ...
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Sanmamed, Miguel ...
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Bosch Campos, An ...
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Patiño-Garcia, A ...
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Schalper, Kurt A ...
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Segura, Victor
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show more...
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Bellmunt, Joaqui ...
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Tabernero, Josep
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Sweeney, Christo ...
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Choueiri, Toni K ...
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Martín, Miguel
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Fusco, Juan Pabl ...
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Rodriguez-Ruiz, ...
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Calvo, Alfonso
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Prior, Celia
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Paz-Ares, Luis
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Pio, Ruben
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Gonzalez-Billala ...
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Gonzalez Hernand ...
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Páez, David
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Piulats, Jose Ma ...
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Gurpide, Alfonso
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Andueza, Mapi
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Velasco, Guiller ...
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Pazo, Roberto
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Grande, Enrique
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Nicolas, Pilar
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Abad-Santos, Fra ...
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Garcia-Donas, Je ...
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Castellano, Dani ...
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Pajares, María J ...
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Suarez, Cristina
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Colomer, Ramon
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Montuenga, Luis ...
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Melero, Ignacio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Treatment ...
- By the university
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Lund University