Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup

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Fältnamn	Indikatorer	Metadata
000		04968naa a2200457 4500
001		oai:lup.lub.lu.se:d7337444-f136-4736-b526-5879f9b50248
003		SwePub
008		190704s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/d7337444-f136-4736-b526-5879f9b502482 URI
024	7	a https://doi.org/10.1016/j.ejca.2019.05.0132 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Allodji, Rodrigue S.u University of Paris-Saclay,University of Birmingham,University of Abomey Calavi (UAC)4 aut
245	1 0	a Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup
264	1	b Elsevier BV,c 2019
300		a 13 s.
520		a Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL. © 2019 Elsevier Ltd
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653		a Childhood cancer survivors
653		a Lymphoid leukaemias
653		a Myeloid leukaemias
653		a Second cancers
653		a Subsequent primary leukaemia
700	1	a Garwicz, Stanislawu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)st6750ga
700	1	a Linge, Helenau Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medk-hjo
700	1	a Wiebe, Thomasu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-twi
700	1	a Hjorth, Larsu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-lhj
700	1	a Reulen, Raoul C.u University of Birmingham4 aut
710	2	a University of Paris-Saclayb University of Birmingham4 org
710	2	a et al.
773	0	t European Journal of Cancerd : Elsevier BVg 117, s. 71-83q 117<71-83x 1879-0852x 0959-8049
856	4	u http://dx.doi.org/10.1016/j.ejca.2019.05.013y FULLTEXT
856	4	u https://boris.unibe.ch/131818/8/Allodji%20EurJCancer%202019_postprint.pdf
856	4 8	u https://lup.lub.lu.se/record/d7337444-f136-4736-b526-5879f9b50248
856	4 8	u https://doi.org/10.1016/j.ejca.2019.05.013

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Av författaren/redakt...: Allodji, Rodrigu ...; Garwicz, Stanisl ...; Linge, Helena; Wiebe, Thomas; Hjorth, Lars; Reulen, Raoul C.

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