Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life:a prospective case–control study

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Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life:a prospective case–control study

Pendleton, Hillevi (author): Lund University,Lunds universitet,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups

Ahlner-Elmqvist, Marianne (author): Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Department of Health Sciences,Faculty of Medicine,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups

Olsson, Rolf (author): Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups

Thorsson, Ola (author): Lund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups

Hammar, Oskar (author): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Jannert, Magnus (author): Lund University,Lunds universitet,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups

Ohlsson, Bodil (author): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

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2013-09-09
2013
English.
In: BMC Ear, Nose and Throat Disorders. - : Springer Science and Business Media LLC. - 1472-6815. ; 13:11

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Journal article (peer-reviewed)

Abstract Subject headings

Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL). Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux in the proximal oesophagus and functional gastrointestinal symptoms, to analyse motilin levels in plasma, and to assess health-related quality of life (HRQOL) before and after treatment. Methods: Forty-six patients (26 women), with verified PL, median age 55 (IQR 41–68) years, were referred to oesophago-gastro-duodenoscopy and 24-h pH monitoring. Plasma motilin was analysed. The 36-item Short-Form questionnaire was completed at inclusion and at follow-up after 43±14 months, when also the Visual Analogue Scale for Irritable Bowel Syndrome was completed. Values were compared to controls. Treatment and relief of symptoms were noted from medical records. Results: Thirty-four percent had proximal acid reflux and 40% showed signs of distal reflux. Ninety-four percent received acid-reducing treatment, with total relief of symptoms in 17%. Patients with reflux symptoms had lower plasma motilin levels compared to patients without reflux symptoms (p = 0.021). The HRQOL was impaired at inclusion, but improved over time. Patients, especially men, had more functional gastrointestinal symptoms than controls. Conclusions: This study indicates that a minority of patients with PL has LPR and is cured by acid-reducing therapy. Disturbed plasma motilin levels and presence of functional gastrointestinal symptoms are found in PL. The impaired HRQOL improves over time.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Keyword

Posterior laryngitis
Laryngo-pharyngeal reflux
Motilin
Functional gastrointestinal disorder
Health-related quality of life

Publication and Content Type

art (subject category)
ref (subject category)

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By the author/editor: Pendleton, Hille ...; Ahlner-Elmqvist, ...; Olsson, Rolf; Thorsson, Ola; Hammar, Oskar; Jannert, Magnus; show more...; Ohlsson, Bodil; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

Articles in the publication: BMC Ear, Nose an ...

By the university: Lund University

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