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Temozolomide therap...
Temozolomide therapy for aggressive pituitary tumours – current understanding and future perspectives
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- Burman, Pia (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital
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- Lamb, Lydia (author)
- Garvan Institute of Medical Research,St Vincent's Hospital, Sydney
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- McCormack, Ann (author)
- Garvan Institute of Medical Research,St Vincent's Hospital, Sydney,University of New South Wales
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(creator_code:org_t)
- 2020-03-09
- 2020
- English 14 s.
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In: Reviews in Endocrine and Metabolic Disorders. - : Springer Science and Business Media LLC. - 1389-9155 .- 1573-2606. ; 21:2, s. 263-276
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Abstract
Subject headings
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- The use of temozolomide (TMZ) for the management of aggressive pituitary tumours (APT) has revolutionised clinical practice in this field with significantly improved clinical outcomes and long-term survival. Its use is now well established however a large number of patients do not respond to treatment and recurrence after cessation of TMZ is common. A number of challenges remain for clinicians such as appropriate patient selection, treatment duration and the role of combination therapy. This review will examine the use of TMZ to treat APT including mechanism of action, treatment regimen and duration; biomarkers predicting response to treatment and patient selection; and current evidence for administration of TMZ in combination with other agents.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Aggressive pituitary tumour
- Biomarker
- Combination therapy
- Pituitary carcinoma
- Temozolomide
Publication and Content Type
- for (subject category)
- ref (subject category)
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