Streptolysin O induces the ubiquitination and degradation of pro-IL-1β

Hancz, Dóra (author): Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups

Westerlund, Elsa (author): Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups

Valfridsson, Christine (author): Lund University,Lunds universitet,Infektionsimmunologi,Forskargrupper vid Lunds universitet,Värd-patogeninteraktioner,Infectious Immunology,Lund University Research Groups,Host-Pathogen Interactions

Aemero, Getachew Melkamu (author): Lund University,Lunds universitet,Virusrekognition,Forskargrupper vid Lunds universitet,Virus Recognition,Lund University Research Groups

Persson, Jenny J. (author): Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups

(creator_code:org_t)

2019-03-19
2019
English.
In: Journal of Innate Immunity. - : S. Karger AG. - 1662-811X .- 1662-8128. ; 11:6, s. 457-468

Related links:: http://dx.doi.org/10... (free); show more...; https://www.karger.c...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

Group A Streptococcus (GAS) is a common and versatile human pathogen causing a variety of diseases. One of the many virulence factors of GAS is the secreted pore-forming cytotoxin streptolysin O (SLO), which has been ascribed multiple properties, including inflammasome activation leading to release of the potent inflammatory cytokine IL-1β from infected macrophages. IL-1β is synthesized as an inactive pro-form, which is activated intracellularly through proteolytic cleavage. Here, we use a macrophage infection model to show that SLO specifically induces ubiquitination and degradation of pro-IL-1β. Ubiquitination was dependent on SLO being released from the infecting bacterium, and pore formation by SLO was required but not sufficient for the induction of ubiquitination. Our data provide evidence for a novel SLO-mediated mechanism of immune regulation, emphasizing the importance of this pore-forming toxin in bacterial virulence and pathogenesis.

By the author/editor: Hancz, Dóra; Westerlund, Elsa; Valfridsson, Chr ...; Aemero, Getachew ...; Bastiat-Sempe, B ...; Orning, Pontus; show more...; Lien, Egil; Wessels, Michael ...; Persson, Jenny J ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.