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id:"swepub:oai:lup.lub.lu.se:e63015f9-c312-48ff-845a-a7459cc47d81"
 

Sökning: id:"swepub:oai:lup.lub.lu.se:e63015f9-c312-48ff-845a-a7459cc47d81" > Resident and pro-in...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003516naa a2200397 4500
001oai:lup.lub.lu.se:e63015f9-c312-48ff-845a-a7459cc47d81
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/37390062 URI
0247 a https://doi.org/10.1038/mi.2012.892 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Bain, C. C.4 aut
2451 0a Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6C(hi) monocyte precursors
264 1b Elsevier BV,c 2013
520 a Macrophages (m phi) are essential for intestinal homeostasis and the pathology of inflammatory bowel disease (IBD), but it is unclear whether discrete m phi populations carry out these distinct functions or if resident m phi change during inflammation. We show here that most resident m phi in resting mouse colon express very high levels of CX3CR1, are avidly phagocytic and MHCII hi, but are resistant to Toll-like receptor (TLR) stimulation, produce interleukin 10 constitutively, and express CD163 and CD206. A smaller population of CX3CR1(int) cells is present in resting colon and it expands during experimental colitis. Ly6C(hi) CCR2(+) monocytes can give rise to all m phi subsets in both healthy and inflamed colon and we show that the CX3CR1int pool represents a continuum in which newly arrived, recently divided monocytes develop into resident CX3CR1 hi m phi. This process is arrested during experimental colitis, resulting in the accumulation of TLR-responsive pro-inflammatory m phi. Phenotypic analysis of human intestinal m phi indicates that analogous processes occur in the normal and Crohn's disease ileum. These studies show for the first time that resident and inflammatory m phi in the intestine represent alternative differentiation outcomes of the same precursor and targeting these events could offer routes for therapeutic intervention in IBD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Scott, C. L.4 aut
7001 a Uronen-Hansson, Heliu Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups4 aut0 (Swepub:lu)med-hiu
7001 a Gudjonsson, Sigurduru Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups4 aut0 (Swepub:lu)urok-sgu
7001 a Jansson, O.4 aut
7001 a Grip, Olofu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-ogr
7001 a Guilliams, M.4 aut
7001 a Malissen, B.4 aut
7001 a Agace, W. W.4 aut
7001 a Mowat, A. Mc I.4 aut
7102 a Slemhinnans immunologib Forskargrupper vid Lunds universitet4 org
7730 t Mucosal Immunologyd : Elsevier BVg 6:3, s. 498-510q 6:3<498-510x 1933-0219
8564 u http://dx.doi.org/10.1038/mi.2012.89y FULLTEXT
8564 u https://www.nature.com/articles/mi201289.pdf
8564 8u https://lup.lub.lu.se/record/3739006
8564 8u https://doi.org/10.1038/mi.2012.89

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