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Early infant diet a...
Early infant diet and islet autoimmunity in the TEDDY study
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- Uusitalo, Ulla (author)
- University of South Florida
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- Lee, Hye Seung (author)
- University of South Florida
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- Aronsson, Carin Andrén (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Vehik, Kendra (author)
- University of South Florida
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- Yang, Jimin (author)
- University of South Florida
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- Hummel, Sandra (author)
- Klinikum rechts der Isar
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- Silvis, Katherine (author)
- Augusta University
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Rewers, Marian (author)
- University of Colorado School of Medicine
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- She, Jin Xiong (author)
- Augusta University
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- Simell, Olli (author)
- University of Turku
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- Toppari, Jorma (author)
- Turku University Hospital
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- Ziegler, Anette G. (author)
- Klinikum rechts der Isar
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey (author)
- University of South Florida
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- Virtanen, Suvi M. (author)
- University of Tampere
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- Norris, Jill M. (author)
- Colorado School of Public Health
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(creator_code:org_t)
- 2018-01-17
- 2018
- English 9 s.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 41:3, s. 522-530
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Abstract
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- OBJECTIVE To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 childrenwith increased genetic risk of type 1 diabetes (T1D) in the U.S., Finland, Germany, and Sweden. This study included 7,563 children with at least 9 months of follow-up. Blood samples were collected every 3 months from birth to evaluate IA, defined as persistent, confirmed positive antibodies to insulin (IAAs), GAD, or insulinoma antigen-2. We examined the associations between diet and the risk of IA using Cox regression models adjusted for country, T1D family history, HLA genotype, sex, and early probiotic exposure. Additionally, we investigated martingale residuals and log-rank statistics to determine cut points for ages of dietary exposures. RESULTS Later introduction of glutenwas associatedwith increased risk of any IA and IAA. The hazard ratios (HRs) for every 1-month delay in gluten introduction were 1.05 (95% CI 1.01, 1.10; P = 0.02) and 1.08 (95% CI 1.00, 1.16; P = 0.04), respectively. Martingale residual analysis suggested that the age at gluten introduction could be grouped as <4, 4-9, and >9 months. The risk of IA associated with introducing gluten before 4months of age was lower (HR 0.68; 95% CI 0.47, 0.99), and the risk of IA associated with introducing it later than the age of 9 months was higher (HR 1.57; 95% CI 1.07, 2.31) than introduction between 4 and 9 months of age. CONCLUSIONS The timing of gluten-containing cereals and IA should be studied further.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
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- By the author/editor
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Uusitalo, Ulla
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Lee, Hye Seung
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Aronsson, Carin ...
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Vehik, Kendra
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Yang, Jimin
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Hummel, Sandra
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show more...
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Silvis, Katherin ...
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Lernmark, Åke
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Rewers, Marian
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Hagopian, Willia ...
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She, Jin Xiong
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Simell, Olli
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Toppari, Jorma
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Ziegler, Anette ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Virtanen, Suvi M ...
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Norris, Jill M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University