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Sökning: id:"swepub:oai:lup.lub.lu.se:f8c418e9-d17c-4539-af5a-88aa6dca6021" > 3D skeletal uptake ...

3D skeletal uptake of F-18 sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer

Lindgren Belal, Sarah (författare)
Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
Sadik, M. (författare)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
Kaboteh, R. (författare)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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Hasani, N. (författare)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
Enqvist, Olof, 1981 (författare)
Chalmers University of Technology
Svarm, L. (författare)
Eigenvision AB
Kahl, Fredrik, 1972 (författare)
Chalmers University of Technology
Simonsen, J. (författare)
Odense University Hospital
Poulsen, M. H. (författare)
Odense University Hospital
Ohlsson, Mattias (författare)
Lund University,Lunds universitet,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science
Hoilund-Carlsen, P. F. (författare)
Odense University Hospital
Edenbrandt, Lars (författare)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
Trägårdh, Elin (författare)
Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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 (creator_code:org_t)
2017-02-16
2017
Engelska.
Ingår i: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 7:1
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer. Methods: NaF PET/CT and bone scans were studied in 48 patients with prostate cancer. Automated segmentation of the thoracic and lumbar spines, sacrum, pelvis, ribs, scapulae, clavicles, and sternum were made in the CT images. Hotspots in the PET images were selected using both a manual and an automated method. The volume of each hotspot localized in the skeleton in the corresponding CT image was calculated. Two PET/CT indices, based on manual (manual PET index) and automatic segmenting using a threshold of SUV 15 (automated PET15 index), were calculated by dividing the sum of all hotspot volumes with the volume of all segmented bones. BSI values were obtained using a software for automated calculations. Results: BSI, manual PET index, and automated PET15 index were all significantly associated with OS and concordance indices were 0.68, 0.69, and 0.70, respectively. The median BSI was 0.39 and patients with a BSI > 0.39 had a significantly shorter median survival time than patients with a BSI 0.53 had a significantly shorter median survival time than patients with a manual PET index 0.11 had a significantly shorter median survival time than patients with an automated PET15 index

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Image Processing (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Imaging biomarker
Prostate cancer
Sodium fluoride
Bone scan index
PET/CT
Bone scan index
Imaging biomarker
PET/CT
Prostate cancer
Sodium fluoride

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