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Sex and gender in i...
Sex and gender in infection and immunity : addressing the bottlenecks from basic science to public health and clinical applications
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- Pasin, Chloé (author)
- University of Zurich,University Hospital of Zurich
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- Consiglio, Camila R. (author)
- Karolinska Institute,Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Huisman, Jana S. (author)
- Massachusetts Institute of Technology,ETH Zürich
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- De Lange, Ann Marie G. (author)
- University of Oslo,Lausanne University Hospital,University of Oxford
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- Peckham, Hannah (author)
- University College London
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- Vallejo-Yagüe, Enriqueta (author)
- ETH Zürich
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- Abela, Irene A. (author)
- University of Zurich,University Hospital of Zurich
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- Islander, Ulrika, 1975 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Neuner-Jehle, Nadia (author)
- University of Zurich,University Hospital of Zurich
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- Pujantell, Maria (author)
- University Medical Center Hamburg-Eppendorf
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- Roth, Olivia (author)
- University of Kiel
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- Schirmer, Melanie (author)
- Technical University of Munich
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- Tepekule, Burcu (author)
- University of Zurich,University Hospital of Zurich
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- Zeeb, Marius (author)
- University of Zurich,University Hospital of Zurich
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- Hachfeld, Anna (author)
- Bern University Hospital
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- Aebi-Popp, Karoline (author)
- Bern University Hospital
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- Kouyos, Roger D. (author)
- University of Zurich,University Hospital of Zurich
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- Bonhoeffer, Sebastian (author)
- ETH Zürich
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Royal Society Open Science. - 2054-5703. ; 10:7
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Abstract
Subject headings
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- Although sex and gender are recognized as major determinants of health and immunity, their role is rarely considered in clinical practice and public health. We identified six bottlenecks preventing the inclusion of sex and gender considerations from basic science to clinical practice, precision medicine and public health policies. (i) A terminology-related bottleneck, linked to the definitions of sex and gender themselves, and the lack of consensus on how to evaluate gender. (ii) A data-related bottleneck, due to gaps in sex-disaggregated data, data on trans/non-binary people and gender identity. (iii) A translational bottleneck, limited by animal models and the underrepresentation of gender minorities in biomedical studies. (iv) A statistical bottleneck, with inappropriate statistical analyses and results interpretation. (v) An ethical bottleneck posed by the underrepresentation of pregnant people and gender minorities in clinical studies. (vi) A structural bottleneck, as systemic bias and discriminations affect not only academic research but also decision makers. We specify guidelines for researchers, scientific journals, funding agencies and academic institutions to address these bottlenecks. Following such guidelines will support the development of more efficient and equitable care strategies for all.
Subject headings
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Genusstudier (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Gender Studies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- bottlenecks
- immunity
- infection
- sex and gender
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Pasin, Chloé
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Consiglio, Camil ...
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Huisman, Jana S.
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De Lange, Ann Ma ...
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Peckham, Hannah
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Vallejo-Yagüe, E ...
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show more...
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Abela, Irene A.
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Islander, Ulrika ...
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Neuner-Jehle, Na ...
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Pujantell, Maria
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Roth, Olivia
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Schirmer, Melani ...
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Tepekule, Burcu
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Zeeb, Marius
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Hachfeld, Anna
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Aebi-Popp, Karol ...
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Kouyos, Roger D.
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Bonhoeffer, Seba ...
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Other Social Sci ...
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and Gender Studies
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Royal Society Op ...
- By the university
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Lund University
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Karolinska Institutet
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University of Gothenburg