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Scavenger Receptors...
Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation
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Arredouani, MS (author)
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Franco, F (author)
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Imrich, A (author)
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Fedulov, A (author)
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Lu, X (author)
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Perkins, D (author)
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Soininen, R (author)
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- Tryggvason, K (author)
- Karolinska Institutet
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Shapiro, SD (author)
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Kobzik, L (author)
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(creator_code:org_t)
- The American Association of Immunologists, 2007
- 2007
- English.
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In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 178:9, s. 5912-5920
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http://www.jimmunol....
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http://kipublication...
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https://doi.org/10.4...
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Abstract
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- The class A scavenger receptors (SR-A) MARCO and SR-AI/II are expressed on lung macrophages (MΦs) and dendritic cells (DCs) and function in innate defenses against inhaled pathogens and particles. Increased expression of SR-As in the lungs of mice in an OVA-asthma model suggested an additional role in modulating responses to an inhaled allergen. After OVA sensitization and aerosol challenge, SR-AI/II and MARCO-deficient mice exhibited greater eosinophilic airway inflammation and airway hyperresponsiveness compared with wild-type mice. A role for simple SR-A-mediated Ag clearance (“scavenging”) by lung MΦs was excluded by the observation of a comparable uptake of fluorescent OVA by wild-type and SR-A-deficient lung MΦs and DCs. In contrast, airway instillation of fluorescent Ag revealed a significantly higher traffic of labeled DCs to thoracic lymph nodes in SR-A-deficient mice than in controls. The increased migration of SR-A-deficient DCs was accompanied by the enhanced proliferation in thoracic lymph nodes of adoptively transferred OVA-specific T cells after airway OVA challenge. The data identify a novel role for SR-As expressed on lung DCs in the down-regulation of specific immune responses to aeroallergens by the reduction of DC migration from the site of Ag uptake to the draining lymph nodes.
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- art (subject category)
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- By the author/editor
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Arredouani, MS
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Franco, F
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Imrich, A
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Fedulov, A
-
Lu, X
-
Perkins, D
-
show more...
-
Soininen, R
-
Tryggvason, K
-
Shapiro, SD
-
Kobzik, L
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show less...
- Articles in the publication
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Journal of immun ...
- By the university
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Karolinska Institutet