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Strong association ...
Strong association between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients
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Gu, Y (author)
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Cheng, LT (author)
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Chen, HM (author)
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Sun, XY (author)
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Tang, LJ (author)
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Guo, LJ (author)
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- Axelsson, J (author)
- Karolinska Institutet
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Wang, T (author)
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(creator_code:org_t)
- 2008-05-16
- 2008
- English.
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In: Blood purification. - : S. Karger AG. - 1421-9735 .- 0253-5068. ; 26:4, s. 340-346
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <i>Background:</i> Malnutrition is a predictor of cardiovascular disease in dialysis patients, but the mechanisms remain unknown. We investigated links between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients. <i>Methods:</i> We evaluated the relationship between arterial stiffness evaluated by pulse-wave velocity (PWV) and four estimates of nutritional status (serum albumin, handgrip strength [HGS], subjective global assessment [SGA], and bioelectrical impedance analysis phase angle [PA]) in 124 PD patients. <i>Results:</i> Malnourished patients exhibited a significantly higher PWV than those classified as well-nourished by SGA (p < 0.05). Furthermore, PWV correlated negatively with albumin, HGS and PA (p < 0.001, respectively). PWV was also correlated with age, systolic blood pressure, and C-reactive protein. In multivariate regression analysis, albumin, HGS, SGA and PA were each independently associated with PWV after adjustment. <i>Conclusions:</i> The significant association between each nutritional marker and PWV in PD patients was independent of inflammation and diabetic state, suggesting that malnutrition may contribute to vascular dysfunction.
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- art (subject category)
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