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The relationship of NT-proBNP and dialysis parameters with outcome of incident haemodialysis patients: results from the membrane permeability outcome study
- Locatelli, F (author)
- Hannedouche, T (author)
- Martin-Malo, A (author)
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- Vanholder, R (author)
- Ronco, C (author)
- La Milia, V (author)
- Gomez, JML (author)
- Stefoni, S (author)
- Maheut, H (author)
- Klinger, M (author)
- Krummel, T (author)
- Dhondt, A (author)
- Berdud, I (author)
- Gauly, A (author)
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- (creator_code:org_t)
- 2013-03-28
- 2013
- English.
- In: Blood purification. - : S. Karger AG. - 1421-9735 .- 0253-5068. ; 35:1-3, s. 216-223
- Journal article (peer-reviewed)
Abstract
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- <b><i>Background/Aims:</i></b> The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. <b><i>Methods:</i></b> N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. <b><i>Results:</i></b> Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. <b><i>Conclusions:</i></b> NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- Locatelli, F
- Hannedouche, T
- Martin-Malo, A
- Jacobson, SH
- Vanholder, R
- Ronco, C
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- La Milia, V
- Gomez, JML
- Stefoni, S
- Maheut, H
- Klinger, M
- Krummel, T
- Dhondt, A
- Berdud, I
- Gauly, A
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