id:"swepub:oai:prod.swepub.kib.ki.se:137080481"
Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:137080481" > Age Related Multipl...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02909naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:137080481 | |
| 003 | SwePub | |
| 008 | 240701s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1370804812 URI |
| 024 | 7 | a https://doi.org/10.1177/13524585176906182 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Manouchehrinia, Au Karolinska Institutet4 aut |
| 245 | 1 0 | a Age Related Multiple Sclerosis Severity Score: Disability ranked by age |
| 264 | c 2017-02-03 | |
| 264 | 1 | b SAGE Publications,c 2017 |
| 520 | a The Multiple Sclerosis Severity Score (MSSS) is obtained by normalising the Expanded Disability Status Scale (EDSS) score for disease duration and has been a valuable tool in cross-sectional studies. Objective: To assess whether use of age rather than the inherently ambiguous disease duration was a feasible approach. Method: We pooled disability data from three population-based cohorts and developed an Age Related Multiple Sclerosis Severity (ARMSS) score by ranking EDSS scores based on the patient’s age at the time of assessment. We established the power to detect a difference between groups afforded by the ARMSS score and assessed its relative consistency over time. Results: The study population included 26058 patients from Sweden ( n = 11846), Canada ( n = 6179) and the United Kingdom ( n = 8033). There was a moderate correlation between EDSS and disease duration ( r = 0.46, 95% confidence interval (CI): 0.45–0.47) and between EDSS and age ( r = 0.44, 95% CI: 0.43–0.45). The ARMSS scores showed comparable power to detect disability differences between groups to the updated and original MSSS. Conclusion: Since age is typically unbiased and readily obtained, and the ARMSS and MSSS were comparable, the ARMSS may provide a more versatile tool and could minimise study biases and loss of statistical power caused by inaccurate or missing onset dates. | |
| 700 | 1 | a Westerlind, Hu Karolinska Institutet4 aut |
| 700 | 1 | a Kingwell, E4 aut |
| 700 | 1 | a Zhu, F4 aut |
| 700 | 1 | a Carruthers, R4 aut |
| 700 | 1 | a Ramanujam, Ru Karolinska Institutet4 aut |
| 700 | 1 | a Ban, M4 aut |
| 700 | 1 | a Glaser, Au Karolinska Institutet4 aut |
| 700 | 1 | a Sawcer, S4 aut |
| 700 | 1 | a Tremlett, H4 aut |
| 700 | 1 | a Hillert, Ju Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Multiple sclerosis (Houndmills, Basingstoke, England)d : SAGE Publicationsg 23:14, s. 1938-1946q 23:14<1938-1946x 1477-0970x 1352-4585 |
| 856 | 4 | u https://journals.sagepub.com/doi/pdf/10.1177/1352458517690618 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:137080481 |
| 856 | 4 8 | u https://doi.org/10.1177/1352458517690618 |
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