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Selective deletion ...
Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression
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Sng, MK (author)
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Chan, JSK (author)
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Teo, ZQ (author)
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Phua, T (author)
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Tan, EHP (author)
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Wee, JWK (author)
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Koh, NJN (author)
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Tan, CK (author)
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Chen, JP (author)
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Pal, MT (author)
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Tong, BMK (author)
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Tnay, YL (author)
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Ng, XR (author)
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Zhu, PC (author)
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Chiba, SS (author)
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Wang, XM (author)
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Wahli, W (author)
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Tan, NS (author)
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- 2018-04-03
- 2018
- English.
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In: Cell discovery. - : Springer Science and Business Media LLC. - 2056-5968. ; 4, s. 15-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions. Nuclear receptor peroxisome-proliferator activated receptors (PPARs) are therapeutic targets for dermal fibrosis, but the contribution of the different PPAR subtypes are poorly understood. Particularly, the role of fibroblast PPARβ/δ in dermal fibrosis has not been elucidated. Thus, we generated a mouse strain with selective deletion of PPARβ/δ in the fibroblast (FSPCre-Pparb/d−/−) and interrogated its epidermal and dermal transcriptome profiles. We uncovered a downregulated gene, leucine-rich alpha-2-glycoprotein-1 (Lrg1), of previously unknown function in skin development and architecture. Our findings suggest that the regulation of Lrg1 by PPARβ/δ in fibroblasts is an important signaling conduit integrating PPARβ/δ and TGFβ1-signaling networks in skin health and disease. Thus, the FSPCre-Pparb/d−/− mouse model could serve as a novel tool in the current gunnery of animal models to better understand dermal fibrosis.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sng, MK
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Chan, JSK
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Teo, ZQ
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Phua, T
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Tan, EHP
-
Wee, JWK
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show more...
-
Koh, NJN
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Tan, CK
-
Chen, JP
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Pal, MT
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Tong, BMK
-
Tnay, YL
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Ng, XR
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Zhu, PC
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Chiba, SS
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Wang, XM
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Wahli, W
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Tan, NS
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show less...
- Articles in the publication
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Cell discovery
- By the university
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Karolinska Institutet