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VEGF-B is a potent antioxidant
- Arjunan, P (author)
- Lin, XC (author)
- Tang, ZS (author)
- show more...
- Du, YX (author)
- Kumar, A (author)
- Liu, LX (author)
- Yin, XK (author)
- Huang, LJ (author)
- Chen, W (author)
- Chen, QS (author)
- Ye, ZM (author)
- Wang, SS (author)
- Kuang, HQ (author)
- Zhou, LB (author)
- Xu, K (author)
- Chen, X (author)
- Zeng, HT (author)
- Lu, WS (author)
- Liu, YZ (author)
- Zhao, C (author)
- Li, XR (author)
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- (creator_code:org_t)
- 2018-09-24
- 2018
- English.
- In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 115:41, s. 10351-10356
- Journal article (peer-reviewed)
Abstract
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- Despite being discovered a long time ago, the functional properties of VEGF-B remain poorly understood. However, several clinical treatments use drugs that target VEGF-B and other VEGF family members. It is therefore crucial to gain deeper insights into the function of VEGF-B and the underlying mechanisms. Here, we found that VEGF-B has potent antioxidative functions, making it a VEGF family member to show such a property. We further identified a critical downstream effector of VEGF-B, Gpx1, through which it protects against retinal degeneration. In addition, being an otherwise “inert” molecule, as shown by previous studies, makes VEGF-B a promising molecule for clinical applications. Our findings suggest that VEGF-B could be a potent therapeutic agent against oxidative stress-related diseases.
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- art (subject category)
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- Arjunan, P
- Lin, XC
- Tang, ZS
- Du, YX
- Kumar, A
- Liu, LX
- show more...
- Yin, XK
- Huang, LJ
- Chen, W
- Chen, QS
- Ye, ZM
- Wang, SS
- Kuang, HQ
- Zhou, LB
- Xu, K
- Chen, X
- Zeng, HT
- Lu, WS
- Cao, YH
- Liu, YZ
- Zhao, C
- Li, XR
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