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Phenalen-1-One-Mediated Antimicrobial Photodynamic Therapy and Chlorhexidine Applied to a Novel Caries Biofilm Model
- Cieplik, F (author)
- Wimmer, F (author)
- Muehler, D (author)
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- Thurnheer, T (author)
- Hiller, KA (author)
- Maisch, T (author)
- Buchalla, W (author)
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- (creator_code:org_t)
- 2018-04-04
- 2018
- English.
- In: Caries research. - : S. Karger AG. - 1421-976X .- 0008-6568. ; 52:6, s. 447-453
- Journal article (peer-reviewed)
Abstract
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- Antimicrobial photodynamic therapy (aPDT) may be useful as a supportive antimicrobial measure for caries-active subjects. In this study, the antimicrobial efficacy of aPDT with a phenalen-1-one photosensitizer was evaluated in a novel in vitro biofilm model comprising <i>Actinomyces naeslundii</i>, <i>Actinomyces odontolyticus</i>, and <i>Streptococcus mutans</i> and was compared to chlorhexidine. The proposed biofilm model allows high-throughput screening for antimicrobial efficacy while exhibiting a differentiated response to different antimicrobial approaches. While chlorhexidine 0.2% showed a reduction of ≈4 log<sub>10</sub> for all species, aPDT led to a more pronounced reduction of <i>S. mutans</i> (2.8 log<sub>10</sub>) than of <i>Actinomyces</i> spp. (1.2 or 1.3 log<sub>10</sub>). A similar effect was also observed in monospecies biofilms. Therefore, aPDT may be more effective against <i>S. mutans</i> than against <i>Actinomyces</i> spp. when in biofilms, and this antimicrobial approach merits further investigations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- Cieplik, F
- Wimmer, F
- Muehler, D
- Thurnheer, T
- Belibasakis, GN
- Hiller, KA
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- Maisch, T
- Buchalla, W
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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- Caries research
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- Karolinska Institutet
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