AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

Cordero-Herrera, I (author)

Kozyra, M (author)

Zhuge, ZB (author)

Haworth, SM (author)

Peleli, M (author)

Caldeira-Dias, M (author)

Jahandideh, A (author)

Han, HR (author)

Cruz, JD (author)

Montenegro, MF (author)

(creator_code:org_t)

2018-12-17
2019
English.
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 116:1, s. 217-226

Related links:: https://www.pnas.org...; show more...; http://kipublication...; https://doi.org/10.1...; show less...

Abstract Subject headings

Liver steatosis, or fatty liver, is the most common liver disease in the world, affecting up to 25% of all Americans. There is currently no approved drug available for this condition, which may progress to serious disease, including steatohepatitis, fibrosis, and cirrhosis. Here, we show in rodent and human models of metabolic syndrome that steatosis can be prevented by a simple dietary approach. Inorganic nitrate, present in green leafy vegetables, is converted in vivo to nitric oxide (NO) in a process involving symbiotic host bacteria. NO then induces key metabolic regulatory pathways to ultimately reduce oxidative stress and improve cardiometabolic functions. Clinical trials would be helpful to tell if dietary nitrate is useful in treatment and prevention of fatty liver disease.

By the author/editor: Cordero-Herrera, ...; Kozyra, M; Zhuge, ZB; Haworth, SM; Moretti, C; Peleli, M; show more...; Caldeira-Dias, M; Jahandideh, A; Han, HR; Cruz, JD; Kleschyov, AL; Montenegro, MF; Ingelman-Sundber ...; Weitzberg, E; Lundberg, JO; Carlstrom, M; show less...

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